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Regulation of endocytosis by the small GTP-ase Rab5

  • Session 2 Intracellular Architecture and Traffic
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Abstract

Rab5 is a small GTPase associated with the plasma membrane and the early endosomes. Expression of wild type rab5 and a mutant protein defective in GTP-binding in BHK cells led to alterations in the rate of endocytosis and in the morphology of endocytic organelles. The results obtained suggest that rab5 is a rate limiting GTPase that regulate the kinetics of both lateral fusion of early endosomes and fusion of plasma membrane-derived endocytic vesicles with early endosomes.

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Authors and Affiliations

  1. European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10.2209, D-6900, Heidelberg, Germany

    M Zerial

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  1. M Zerial
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Zerial, M. Regulation of endocytosis by the small GTP-ase Rab5. Cytotechnology 11 (Suppl 1), S47–S49 (1993). https://doi.org/10.1007/BF00746052

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  • DOI: https://doi.org/10.1007/BF00746052

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