Abstract
The lack of efficient and specific delivery to target cells still limits the potential application of antisense oligodeoxynucleotides as therapeutic agents in cancer disease. We have covalently linked a polylysine chain (10,000–20,000 mW) to compounds as folic acid, retinoic acid, transferrin, insulin and estradiol, to deliver c-myb antisense oligonucleotide into tumor cells. Using these complexes as carriers for the oligodeoxynucleotides can be achieved an increase in their uptake into target cells through a natural endocytosis pathway.
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Citro, G., Ginobbi, P. & Szczylik, C. Receptor-mediated oligodeoxynucleotides delivery by estradiol and folic acid polylysine conjugates. Cytotechnology 11 (Suppl 1), S30–S34 (1993). https://doi.org/10.1007/BF00746048
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DOI: https://doi.org/10.1007/BF00746048