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Researches on 2, l, 3-thia- and selenadiazole

XL. Di(β-chloroethyl)-amino derivatives

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Chemistry of Heterocyclic Compounds Aims and scope

Abstract

4-(β,β-Dicarboethoxy-β-acetylamino) ethyl-7-aminobenzo-2,1, 3-thiadiazole (IV) and ethylene oxide form mainly the 7-(β-hydroxyethyl) amino derivative (V); the 7- di (β-hydroxyethyl) amino derivative VII was isolated in low yield. Action of POCl3 on compound VII gave the 7-di (β-chloroethyl) amino derivative VIII, which was converted into 4-(β-amino-β-carboxy)-ethyl-7 -di (β-chloroethyl) aminobenzo-2, 1, 3-thiadiazole (IX). 5-(β, β-dicarboethoxy-β-acetylamino) ethyl-4-nitrobenzo-2, 1, 3-thiadiazole (XI) was converted to 5-(β-carboxy-β-amino) ethyl-4-nitrobenzo-2, 1, 3-thiadiazole hydrochloride (XII), from which was prepared, by known routes, and in satisfactory yield, 5-(β-carboxy-β-amino) ethyl-4-di (β-chloroethyl)-aminobenzo-2, l, 3-thiadiazole hydrochloride (XVII).

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For Part XXXIX see [8].

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Pesin, V.G., D'yachenko, S.A. Researches on 2, l, 3-thia- and selenadiazole. Chem Heterocycl Compd 2, 276–279 (1967). https://doi.org/10.1007/BF00742366

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  • DOI: https://doi.org/10.1007/BF00742366

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