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Cellular internalisation of bacterial toxins

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References

  1. Barroso L.A., Wang S.-Z., Phelps C.J., Johnson J.L., and Wilkins T.D. (1990) ‘Nucleotide sequence ofClostridium difficile toxin B gene’, Nucleic Acids Research 18,4004.

    Google Scholar 

  2. Dove C.H., Wang S.Z., Price S.B., Phelps C.J., Lyerly D.M., Wilkins T.D., and Johnson J.L. (1990) ‘Molecular characterization of theClostridium difficile toxin A gene’, Infect. Immun. 58, 480–488.

    Google Scholar 

  3. Eiklid K. and Olsnes S. (1983) ‘Entry ofShigella dysenteriae toxin into HeLa cells’, Infect. Immun. 42, 771–777.

    Google Scholar 

  4. Fiorentini C., Arancia G., Paradisi S., Donelli G., Giuliano M., Piemonte F., and Mastrantonio P. (1989) ‘Effects ofClostridium difficile toxins A and B on cytoskeleton organization in HEp-2 cells: a comparative morphological study’, Toxicon 27, 1209–1218.

    Google Scholar 

  5. Florin I. and Thelestam M. (1983) ‘Internalization ofClostridium difficile cytotoxin into cultured human lung fibroblasts’, Biochim. Biophys. Acta 763, 383–392.

    Google Scholar 

  6. Florin I. and Thelestam M. (1986) ‘Lysosomal involvement in cellular intoxication withClostridium difficile toxin B’, Microb. Pathogen. 1, 373–385.

    Google Scholar 

  7. Henriques B., Florin I., and Thelestam M. (1987) ‘Cellular internalisation ofClostridium difficile toxin A’, Microb. Pathogen. 2, 455–463.

    Google Scholar 

  8. Hughes R.C. (1979) ‘How do toxins penetrate cells?’, Nature 281, 526–527.

    Google Scholar 

  9. Kagan B.L., Finkelstein A., and Colombini M. (1981) ‘Diphtheria toxin fragment forms large pores in phospholipid bilayer membranes’, Proc. Natl. Acad. Sci. USA 78, 4950–4954.

    Google Scholar 

  10. Kushnaryov V.M. and Sedmak J.J. (1989) ‘Effect ofClostridium difficile enterotoxin A on ultrastructure of chinese hamster ovary cells’, Infect. Immun. 57, 3914–3921.

    Google Scholar 

  11. Marnell M.H., Shia S-P., Stookey M., and Draper R.K. (1984) ‘Evidence for penetration of diphtheria toxin to the cytosol through a prelysosomal membrane’, Infect. Immun. 44, 145–150.

    Google Scholar 

  12. Montecucco C., Shiavo G., and Tomasi M. (1985) ‘pH-dependence of the phospholipid interaction of diphtheria-toxin fragments’, Biochem. J. 231, 123–128.

    Google Scholar 

  13. Morris R.E. and Saelinger C.B. (1986) ‘Reduced temperature altersPseudomonas exotoxin A entry into the mouse LM cell’, Infect. Immun. 52, 445–453.

    Google Scholar 

  14. Moskaug J.O., Sandvig K., and Olsnes S. (1989) ‘Role of anions in low pH-induced translocation of diphtheria toxin’, J. Biol. Chem. 264, 11367–11372.

    Google Scholar 

  15. Moya M., Dautry-Varsat A., Goud B., Louvard D., and Boquet P. (1985) ‘Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin’, J. Cell. Biol. 101, 548–559.

    Google Scholar 

  16. Olsnes S. and Sandvig K. (1988) ‘How protein toxins enter and kill cells’, in A.E.Frankel (ed.), Immunotoxins, Kluwer Academic Publishers, Dordrecht, pp. 39–73.

    Google Scholar 

  17. Stenmark H., Olsnes S., and Sandvig K. (1988) ‘Requirement of specific receptors for efficient translocation of diphtheria toxin A fragment across the plasma membrane’, J. Biol. Chem. 263, 13449–13455.

    Google Scholar 

  18. Taylor N.S., Thorne G.M., and Bartlett J.G. ‘Comparison of two toxins produced byClostridium difficile’, Infect. Immun. 34, 1036–1043.

  19. Thelestam M. and Florin I. (1984) ‘Cytopathogenic action ofClostridium difficile toxins’, J. Toxicol.-Toxin Reviews 3, 139–180.

    Google Scholar 

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Thelestam, M. Cellular internalisation of bacterial toxins. Cytotechnology 5 (Suppl 1), 63–66 (1991). https://doi.org/10.1007/BF00736811

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