Summary
The relationship between cognitive impairment in multiple sclerosis and brain lesions seen on magnetic resonance imaging (MRI) was studied. Three groups of 11 patients with multiple sclerosis, matched for the variables of disability, duration of illness, age and sex, were included. On the basis of neuropsychological testing, the groups were seen to differ in their level of cognitive impairment. The first group showed no cognitive impairment, the second group a moderate, and the third group a serious cognitive impairment. These differences between the groups were reflected by MRI, which revealed more abnormalities in the groups with cognitive impairment compared with the group with normal cognitive function. However, by MRI it was not possible to distinguish between the groups with moderate and that with serious cognitive impairment.
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References
Albert ML (1978) Subcortical dementia. In: Katzman R, Terry RD, Bick KL (eds) Alzheimer's disease: senile dementia and related disorders. Raven, New York, pp 173–180
Appel B, Engelen H, Moens E, Mortelmans L, Löwenthal A (1987) Clinical evaluation of the first 365 patients with a 0.15 Tesla resistic NMR-system. Acta Neurol Belg (in press)
Beatty PA, Gange JJ (1977) Neuropsychological aspects of multiple sclerosis. J Nerv Ment Dis 1964:42–50
Brooks DJ, Leendert KL, Head G, Marshal J, Legg NJ, Jones T (1984) Studies on regional cerebral oxygen utilisation and cognitive function in multiple sclerosis. J Neurol Neurosurg Psychiatry 47:1182–1191
DeSmedt L, Swerts M, Geutjens J, Medaer R (1984) Intellectual impairment in multiple sclerosis. In: Gonsette RE, Delmotte P (eds) Immunological and clinical aspects of multiple sclerosis. MTP Press, Lancaster, pp 342–345
Diers WC, Brown CC (1950) Psychometric patterns associated with multiple sclerosis. Arch Neurol Psychiatr 63:760–765
Gebarski SS, Gabrielsen TO, Gilman S, Knake JE, Lattack JT, Aisen AM (1985) The initial diagnosis of multiple sclerosis: clinical impact of magnetic resonance imaging. Ann Neurol 17:469–474
Grant I, McDonald WI, Trimble MR, Smith E, Reed R (1984) Deficient learning and memory in early and middle phases of multiple sclerosis. J Neurol Neurosurg Psychiatry 47:250–255
Ivnik RJ (1978) Neuropsychological stability in multiple sclerosis. J Consult Clin Psychol 46:913–923
Jackson JA, Leake DR, Schneiders NJ, Rolak LA, Kelley GR, Ford JJ, Appel SH, Bryan RN (1985) Magnetic resonance imaging in multiple sclerosis: results in 32 cases. AJNR 6:171–176
Jacobs L, Kinkel WR, Polachini I, Kinkel RP (1986). Correlations of nuclear magnetic resonance imaging, computerized tomography, and clinical profiles in multiple sclerosis. Neurology 36:27–34
Jambor KL (1969) Cognitive functioning in multiple sclerosis. Br J Psychiatry 115:765–775
Joynt RJ, Shoulson I (1979) Dementia. In: Heilman KM, Valenstein E (eds) Clinical neuropsychology. Oxford University Press, New York, pp 475–502
Kaplan R (1984) Substantive and methodological issues in a rating of cognitive and psychological function in multiple sclerosis. Acta Neurol Scand [Suppl 101] 70:21–28
Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444–1452
Li D, Mayo J, Fache S, Robertson W, Kastrukoff LF, Oger J, Paty DW (1984) Lack of correlation between clinical manifestations and lesions of multiple sclerosis as seen by NMR. Neurology [Suppl 1] 34:136
Lukes SA, Crooks LE, Aminoff MJ, Kaufman L, Panitch HS, Mills C, Norman D (1983) Nuclear magnetic resonance imaging in multiple sclerosis. Ann Neurol 13:592–601
Luria AR (1973) The working brain: an introduction to neuropsychology. Basic Books, New York
Peyser JM, Becker B (1984) Neuropsychological evaluation in patients with multiple sclerosis. In: Poser CM, Paty DW, Scheinberg L, McDonald WI, Ebers GC (eds) The diagnosis of multiple sclerosis. Thieme-Stratton, New York, pp 143–158
Peyser JM, Edwards KR, Poser CM, Filskov SB (1980) Cognitive function in patients with multiple sclerosis. Arch Neurol 37:577–579
Poser CM (1980) Exacerbations, activity, and progression in multiple sclerosis. Arch Neurol 37:471–474
Poser CM, Paty DW, Scheinberg L, McDonald I, Davis F, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–231
Rao SM, Hammeke JA, McQuillen MP, Khatri BO, Lloyd DD (1984) Memory disturbance in chronic, progressive multiple sclerosis. Arch Neurol 41:625–636
Rao SM, Glatt S, Hammeke TA, McQuillen MP, Khatri BO, Rhodes AM, Pollard S (1985) Chronic progressive multiple sclerosis: relationship between cerebral ventricular size and neuropsychological impairment. Arch Neurol 42:678–682
Young IR, Hall AS, Pallis CA, Legg NJ, Bydder GM, Steiner RE (1981) Nuclear magnetic resonance imaging of the brain in multiple sclerosis. Lancet II:1063–1066
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Medaer, R., Nelissen, E., Appel, B. et al. Magnetic resonance imaging and cognitive functioning in multiple sclerosis. J Neurol 235, 86–89 (1987). https://doi.org/10.1007/BF00718015
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DOI: https://doi.org/10.1007/BF00718015