Synthesis of the C-end of the tetrapeptide gastrin
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1. The carbobenzoxy derivative of the C-terminal tetrapeptide of gastrin—the amide of carbobenzoxytryptophanyl-methionylaspartylphenylalanine—has been synthesized by two different routes.
2. In nonnarcotized cats the tetrapeptide obtained causes the secretion of gastric juice with a high content of hydrochloric acid (MR50=11.5 µg/kg).
KeywordsMethyl Ester Dipeptide Hydrazide Sodium Bicarbonate Solution Oily Residue
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