Chemistry of Natural Compounds

, Volume 5, Issue 4, pp 241–243 | Cite as

Synthesis of the C-end of the tetrapeptide gastrin

  • Z. A. Atare
  • V. S. Vilka
  • G. I. Chipens


1. The carbobenzoxy derivative of the C-terminal tetrapeptide of gastrin—the amide of carbobenzoxytryptophanyl-methionylaspartylphenylalanine—has been synthesized by two different routes.

2. In nonnarcotized cats the tetrapeptide obtained causes the secretion of gastric juice with a high content of hydrochloric acid (MR50=11.5 µg/kg).


Methyl Ester Dipeptide Hydrazide Sodium Bicarbonate Solution Oily Residue 


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Copyright information

© Consultants Bureau 1972

Authors and Affiliations

  • Z. A. Atare
    • 1
  • V. S. Vilka
    • 1
  • G. I. Chipens
    • 1
  1. 1.Institute of Organic Synthesis, AS LatvSSRUSSR

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