Chemistry of Natural Compounds

, Volume 5, Issue 4, pp 213–216 | Cite as

Stereoscopic synthesis of 4β-deutero-Δ5-3-ketosteroids

  • G. M. Segal
  • T. S. Fradkina
  • I. V. Torgov


Simple methods for the stereospecific synthesis of 4β-deutero-Δ5-3-ketosteroids have been developed involving the reduction of 3-acetoxy-Δ3, 5-steroids with lithium aluminum hydride and subsequent decomposition with deuterium oxide and Jones oxidation and also the boiling of 5α, 6β-dibromo-3-ketosteroids with zinc dust in deuteroacetic acid.


Deuterium Deuterium Oxide Zinc Dust Lithium Aluminum Hydride Diglyme 


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Copyright information

© Consultants Bureau 1972

Authors and Affiliations

  • G. M. Segal
    • 1
  • T. S. Fradkina
    • 1
  • I. V. Torgov
    • 1
  1. 1.Institute of the Chemistry of Natural Compounds AS USSRUSSR

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