Chemistry of Natural Compounds

, Volume 5, Issue 3, pp 128–132 | Cite as

Reduction of 20-oxosteroids to 20α-alcohols by means ofActinomyces roseochromogenus

  • Leonid M. Kogan
  • E. A. Elin
  • V. I. Mel'nikova
  • I. V. Torgov


A culture ofActinomyces roseochromogenus ATCC 3347 and the corresponding cell-free preparation reduce 17α-oxygen-containing 20-oxopregnanes to the 20α-alcohol. A culture ofA. roseochromogenus ATCC 3347 is capable of reducing Δ4-3-oxo- to 3β-hydroxy-5α-steroids, as has been shown by fermentation with 16α, 17-epoxyprogesterone as an example. It has been shown that certain substituents in the steroid molecule affect the course of the 20α-reduction by a culture ofA. roseochromogenus ATCC 3347.


Hydroxyprogesterone Oily Residue Isonicotinic Acid Hydrazide Sodium Ethyl Cortexolone 


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Copyright information

© Consultants Bureau 1972

Authors and Affiliations

  • Leonid M. Kogan
    • 1
  • E. A. Elin
    • 1
  • V. I. Mel'nikova
    • 1
  • I. V. Torgov
    • 1
  1. 1.Institute of the Chemistry of Natural Compounds, AS USSRUSSR

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