Chemistry of Heterocyclic Compounds

, Volume 27, Issue 1, pp 55–60 | Cite as

Aminomethylation of 1-R-Tetrazoles

  • V. P. Karavai
  • P. N. Gaponik


The reaction of tetrazole and a series of its 1-substituted derivatives with formaldehyde and alkylamines under mild conditions results in aminomethylation of the heterocyclic ring at the carbon atom with the formation of the corresponding Mannich bases. It was found that strong acids (HCl and CF3COOH) have an activating action during the process. An ylide mechanism of the reaction was proposed from the data obtained.


Formaldehyde Organic Chemistry Carbon Atom Tetrazole Mild Condition 
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Copyright information

© Plenum Publishing Corporation 1991

Authors and Affiliations

  • V. P. Karavai
    • 1
  • P. N. Gaponik
    • 1
  1. 1.Scientific Research Institute of Physicochemical ProblemsV. I. Lenin Belorussian State UniversityMinsk

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