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The significance of the abnormal rest Thallium-201 myocardial image in coronary artery disease

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Abstract

Rest Thallium-201 myocardial images were abnormal in 20 out of 40 patients with arteriographically proven coronary artery disease. The myocardial image appearances did not accurately reflect the extent of coronary artery disease present. However, in 35 of the 40 patients (88%) the presence or absence of abnormalities on the rest myocardial image correleted respectively with the presence or absence of abnormal wall motion at left ventriculography. Most rest image abnormalities could be attributed to previous myocardial infarction, but in six patients myocardial ischaemia was possibly the cause. These results suggest that though myocardial fibrosis is usually the cause of rest myocardial image abnormalities in coronary artery disease, this is not invariably so. The possible therapeutic implications are discussed.

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References

  • Adelstein, S.J., Maseri, A.: Radio-indicators for the study of the heart: principles and applications. Prog. Card. Dis.20, 3–17 (1977)

    Google Scholar 

  • Bailey, I.K., Griffith, L.S.C., Rouleau, J., Strauss, H.W., Pitt, B.: Thallium-201 myocardial perfusion imaging at rest and during exercise. Comparative sensitivity to electrocardiography in coronary artery disease. Circulation55, 79–87 (1977)

    Google Scholar 

  • Bull, N., Niendorf, H.P., Strauer, B.E., Hast, B.: Evaluation of myocardial function with the 201 Thallium scintimetry in various diseases of the heart. Eur. J. Nucl. Med.1, 125–136 (1976)

    Google Scholar 

  • Cox, C.J.C.: Return to normal of the electrocardiogram after myocardial infarction. Lancet1, 1194–1197 (1967)

    Google Scholar 

  • Dyke, S.H., Cohn, P.F., Gorlin, R., Sonnenblick, E.H.: Detection of residual myocardial function in coronary artery disease using post extra systolic potentiation. Circulation50, 694–699 (1974)

    Google Scholar 

  • Gewirtz, H., Beller, G.A., Strauss, H.W., Dinsmore, R.E., McKusick, K.A., Zir, L.M., Pohost, G.M.: Transient defects on resting Thallium scans in patients with coronary artery disease. Am. J. Cardiol.41, 380 (1978) (abstract)

    Google Scholar 

  • Gould, K.L., Hamilton, G.W., Lipscomb, K., Ritchie, J.L., Kennedy, J.W.: Method for assessing stress induced regional malperfusion during coronary arteriography. Experimental validation and clinical application. Am. J. Cardiol.34, 557–564 (1974)

    Google Scholar 

  • Helfant, R.H., Pine, R., Meister, S.G., Feldman, M.S., Trout, R.G., Banka, V.S.: Nitroglycerin to unmask reversible asynergy. Correlation with post coronary bypass ventriculography. Circulation50, 108–113 (1974)

    Google Scholar 

  • Hutchins, G.M., Bulkley, B.H., Ridolfi, R.L., Griffith, L.S.C., Lohr, F.T., Piasio, M.A.: Correlations of coronary arteriograms and left ventriculograms with post mortem studies. Circulation56, 32–37 (1977)

    Google Scholar 

  • Kalbfleisch, J.M., Shadaksharappa, K.S., Conrad, L.L., Sarkar, N.K.: Disappearance of the Q deflection following myocardial infarction. Am. Heart J.76, 193–198 (1968)

    Google Scholar 

  • Kaplan, B.M., Berkson, D.M.: Serial electrocardiograms after myocardial infarction. Ann. Int. Med.60, 430–435 (1964)

    Google Scholar 

  • Lenaers, A., Block, P., van Thiel, E., Lebedelle, H., Becquevort, P., Erbsmann, F., Ermans, A.M.: Segmental analysis of T1-201 stress myocardial scintigraphy. J. Nucl. Med.18, 509–516 (1977)

    Google Scholar 

  • Margolis, J.R., Kannel, W.B., Feinleib, M., Dawber, T.R., McNamara, P.M.: Clinical features of unrecognised myocardial infarction — silent and symptomatic. Eighteen year follow up: The Framingham Study. Am. J. Cardiol.32, 1–7 (1973)

    Google Scholar 

  • McKillop, J.H., Murray, R.G., Turner, J.G., Gray, H.W., Bessent, R.G., Lorimer, A.R., Greig, W.R.: Thallium-201 myocardial imaging in the detection of coronary artery disease: sensitivity and specificity. Radioaktive Isotope in Klinik und Forschung,13, 257–264 (1978a)

    Google Scholar 

  • McKillop, J.H., Turner, J.G., Gray, H.W., Bessent, R.G., Greig, W.R.: The clinical value of delayed Thallium-201 myocardial imaging in suspected acute myocardial infarction. Brit. Heart J.40, 870–873 (1978b)

    Google Scholar 

  • McKillop, J.H., Bessent, R.G., Murray, R.G., Turner, J.G., Tweddel, A., Greig, W.R.: A quantitative approach to the analysis of the normal Thallium-201 myocardial image. Eur. J. Nucl. Med.3, 223–225 (1978c)

    Google Scholar 

  • Pitt, B., Strauss, H.W.: Myocardial imaging in the non invasive evaluation of patients with suspected ischaemic heart disease. Am. J. Cardiol.37, 797–805 (1976)

    Google Scholar 

  • Pond, M., Rehn, T., Burow, R. Pitt, B.: Early detection of myocardial infarction by serial Thallium-201 imaging. Circulation56, (Suppl III), III-230 (1977) (abstract)

    Google Scholar 

  • Ritchie, J.L., Trobaugh, G.B., Hamilton, G.W., Gould, K.L., Narahara, K.A., Murray, J.A., Williams, D.L.: Myocardial imaging with Thallium-201 at rest and during exercise. Comparison with coronary arteriography and resting and stress electrocardiography. Circulation56, 66–71 (1977)

    Google Scholar 

  • Rosenblatt, A., Lowenstein, J.M., Kerth, W., Handmaker, H.: Post exercise Thallium-201 myocardial scanning: a clinical appraisal. Am. Heart J.94, 463–470 (1977)

    Google Scholar 

  • Strauss, H.W., Harrison, K., Langan, J.K., Lebowitz, E., Pitt, B.: Thallium-201 for myocardial imaging: Relation of T1 201 to regional myocardial perfusion. Circulation51, 641–645 (1975)

    Google Scholar 

  • Wackers, F.J.Th., Sokole, E.B., Samson, G., van der Schoot, J.B., Lie, K.I., Liem, K.L., Wellens, H.J.J.: Value and limitations of Thallium-201 scintigraphy in the acute phase of myocardial infarction. N. Engl. J. Med.295, 1–5 (1976)

    Google Scholar 

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McKillop, J.H., Murray, R.G., Bessent, R.G. et al. The significance of the abnormal rest Thallium-201 myocardial image in coronary artery disease. Eur J Nucl Med 4, 83–86 (1979). https://doi.org/10.1007/BF00626075

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