Abstract
In order to study the connection between the structure of sulfanilamides and their antibacterial action, sulfanilamide derivatives of 1- and 2-methyl-5-aminotetrazoles and of 1,3-dimethyl-5-iminotetrazole have been synthesized. A study of their IR spectra has shown that 1-methyl-5-sulfanilimidotetrazole has the imide structure in the crystalline state and 2-methyl-5-sulfanilamidotetrazole the amide structure. The sulfanilamide derivatives of 1- and 2-methyl-5-aminotetrazoles possess a considerable antibacterial activity, while 1, 3-dimethyl-5-sulfanilimidotetrazole is inactive.
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For communication V, see [1].
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Shchipanov, V.P., Postovskii, I.Y. & Rysakova, E.I. On the tautomerism of 5-aminotetrazole. Chemistry of Heterocyclic Compounds 4, 161–163 (1970). https://doi.org/10.1007/BF00601109
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DOI: https://doi.org/10.1007/BF00601109