Abstract
The influence of esters of N-(β-hydroxypropyl)pyridines (alkyl radicals from CH3 to C4H9) on the enzymatic activity of acetylcholinesterase (ACE) from human blood erythrocytes and on that of butyrylcholinesterase (BCE) from horse blood serum has been studied. At pH 7.5 and 25°C the majority of the piperidine derivatives inhibit reversibly (by the competitive type of inhibition) both ACE and BCE, their inhibiting properties depending only slightly on the presence of the corresponding alkyl radicals in the acid part of the molecule.
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Literature cited
A. P. Brestkin, I. L. Brick, and G. M. Grigor'eva, Int. Pharmacol. Ther. Sect., 85,5, 241 (1973).
S. N. Golikov, and V. I. Rozengart, Cholinesterases and Anticholinesterase Agents [in Russian], Leningrad (1964).
A. S. Sadykov, E. V. Rozengart, A. A. Abduvakhabov, and Kh. A. Aslanov, Cholinesterases, Active Site and Action Mechanism [in Russian], Tashkent (1976).
A. P. Brestkin, E. V. Rozengart, I. N. Soboleva, N. V. Khromov-Borisov, and L. N. Tikhonova, Biokhimiya,40, 95 (1975).
A. A. Abduvakhabov, A. A. Sadykov, D. N. Dalimov, and Kh. A. Aslanov, Alkaloids and Their Derivatives as Tools for the Study of the Cholinergic System [in Russian], Tashkent (1984).
E. V. Rozengart, I. N. Soboleva, N. L. Indenbom, L. N. Tikhonova, and N. V. Khromov-Borisov, Dokl. Akad. Nauk, SSSR,209, 482 (1973).
Sh. K. Kasymov, A. A. Abduvakhabov, Kh. A. Aslanov, and E. V. Rozengart, Uzb. Khim. Zh.,3, 38 (1975).
V. I. Rozengart and O. E. Sherstobitov, The Selective Toxicity of Organophosphorus Insectoacaricides [in Russian], Leningrad (1978).
M. I. Kabachnik, A. A. Abduvakhabov, I. I. Agabekova, A. P. Brestkin, R. I. Volkova, N. N. Godovikov, E. I. Godyna, S. S. Mikhailov, M. Ya. Mikhel'son, V. I. Rozengart, E. V. Rozengart, and R. V. Sitkevich, Usp. Khim.,39, 1050 (1970).
G. L. Ellman, D. R. Cenntney, V. Anders, and K. M. Reather, Biochem. Pharm.,7, 88 (1961).
V. A. Yakovleb, The Kinetics of Enzymatic Catalysis [in Russian], Moscow (1965).
A. Cornish-Bowden, Principles of Enzyme Kinetics, Butterworths, London (1976).
Additional information
Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 763–766, November–December, 1986.
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Dobren'kov, A.G., Tulyabaev, Z., Dalimov, D.N. et al. Interaction of the cholinesterases of warm-blooded animals with esters of N-(β-hydroxypropyl)piperidines and the methiodides. Chem Nat Compd 22, 709–712 (1986). https://doi.org/10.1007/BF00598359
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DOI: https://doi.org/10.1007/BF00598359