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Chemistry of Natural Compounds

, Volume 22, Issue 6, pp 706–709 | Cite as

Synthesis of a heptapeptide forming a modified ACTH 4–10 fragment

  • E. P. Krysin
  • V. N. Karel'skii
  • A. K. Rabinovich
  • S. Yu. Borovkova
Article
  • 29 Downloads

Abstract

A scheme is given for the synthesis of a heptapeptide representing a modified ACTH 4–10 fragment on the basis of which it is possible to create a preparation that is an effective adaptogen of peptide nature. A proposed variant of the synthesis permits a peptide with an adequate degree of purity to be obtained comparatively simply on a larger scale. The intermediate compounds and the final products were obtained with good yields and were distinguished by chromatographic homogeneity. The heptapeptide synthesized did not differ with respect to its physicochemical characteristics and biological action from the analogous compound obtained previously. Some physicochemical characteristics of the compound obtained (angles of optical rotation, chromatographic mobilities) are given.

Keywords

DMFA Mixed Anhydride Benzyloxycarbonyl Palladium Black Laboratory Scheme 

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Literature cited

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    E. Schroeder and K. Lübke, The Peptides, Academic Press, New York (1965).Google Scholar

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • E. P. Krysin
  • V. N. Karel'skii
  • A. K. Rabinovich
  • S. Yu. Borovkova

There are no affiliations available

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