Bradykinin-potentiating peptide from venom of the spider Latrodectus tredecimguttatus

Abstract

A bradykinin-potentiating peptide has been isolated from the venom of the spiderLatrodectus tredecimguttatus. Its physicochemical properties and amino acid composition have been investigated in detail. It has been shown by biological testing on isolated neck of the rat uterus that the peptide increases the contractile effect of bradykinin in in vitro experiments. The “potentiating unit” is 2 · 10−3 mg/ml. A 50% increase in the hypotensive effect of bradykinin at a concentration of the bradykinin-potentiating peptide of 15 µg/kg of body weight has been found, the increase in the intensity of the effect being accompanied by a prolongation of its action.

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Additional information

A. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 699–703, September–October, 1989.

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Sosnina, N.A., Golbenko, Z., Akhunov, A.A. et al. Bradykinin-potentiating peptide from venom of the spider Latrodectus tredecimguttatus. Chem Nat Compd 25, 596–599 (1989). https://doi.org/10.1007/BF00598083

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Keywords

  • Bradykinin
  • Inositol Phosphate
  • Hypotensive Effect
  • Contractile Effect
  • Phytin