Stereoselective synthesis of N,N′-diacyl-p-menthane-1,8-diamines


It has been shown that the interaction of terpin hydrate with various nitriles under the conditions of the Ritter reaction takes place stereoselectively and leads to the formation of a mixture of isomeric cis- and trans-N,N′-diacyl-p-methane-1,8-diamines in a ratio of 1:4. The structures of the products have been shown by1H and13C NMR spectroscopy.

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Institute of Physical Organic Chemistry, Academy of Sciences of the Belorussian SSR, Minsk. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 649–655, September–October, 1989.

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Kovals'skaya, S.S., Kozlov, N.G. & Tikhonova, T.S. Stereoselective synthesis of N,N′-diacyl-p-menthane-1,8-diamines. Chem Nat Compd 25, 552–557 (1989).

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  • Diamine
  • Limonene
  • Diamide
  • Betulin
  • Lupeol