Chemistry of Natural Compounds

, Volume 18, Issue 1, pp 85–89 | Cite as

Synthesis of regular polypeptides including polyfunctional amino acids

  • Sh. Kh. Khalikov
  • M. I. Ismailov
  • S. V. Alieva
  • R. V. Valiev


Polypeptides of regular structure with the sequences His-Glu, Ser-Glu, Try-Glu, His-Tyr, and Glu-His have been synthesized by the 2,4,5-trichlorophenyl ester method. Polymerization was carried out in dimethyl sulfoxide and dimethylformamide. The polymers were purified by dialysis against water. In the process of synthesizing the monomers, theα-amino groups of the acids were protected by ortho-nitrophenylsulfenyl (o-NPS-), benzyloxycarbonyl (Z-), and tert-butoxycarbonyl (t-BOC-) groups. The imidazole group of histidine was Z-protected, and the γ-hydroxy group of glutamic acid and the phenolic OH group of tyrosine were benzyl-protected (Bzl-).


Et3N CF3COOH Benzyloxycarbonyl Absolute Ether Dcha 


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Copyright information

© Plenum Publishing Corporation 1983

Authors and Affiliations

  • Sh. Kh. Khalikov
  • M. I. Ismailov
  • S. V. Alieva
  • R. V. Valiev

There are no affiliations available

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