Synthesis of regular polypeptides including polyfunctional amino acids
- 34 Downloads
Polypeptides of regular structure with the sequences His-Glu, Ser-Glu, Try-Glu, His-Tyr, and Glu-His have been synthesized by the 2,4,5-trichlorophenyl ester method. Polymerization was carried out in dimethyl sulfoxide and dimethylformamide. The polymers were purified by dialysis against water. In the process of synthesizing the monomers, theα-amino groups of the acids were protected by ortho-nitrophenylsulfenyl (o-NPS-), benzyloxycarbonyl (Z-), and tert-butoxycarbonyl (t-BOC-) groups. The imidazole group of histidine was Z-protected, and the γ-hydroxy group of glutamic acid and the phenolic OH group of tyrosine were benzyl-protected (Bzl-).
KeywordsEt3N CF3COOH Benzyloxycarbonyl Absolute Ether Dcha
Unable to display preview. Download preview PDF.
- 2.V. A. Shibnev, M. I. Ismailov, Sh. Kh. Khalikov, and I. Yu. Lakizova, Khim. Prir. Soedin., 687 (1979).Google Scholar
- 3.V. A. Shibnev, Sh. Kh. Khalikov, M. I. Ismailov, and S. V. Alieva, Dokl. Akad. Nauk TadzhSSR,19, No. 1, 35 (1976).Google Scholar
- 4.Sh. Kh. Khalikov, M. I. Ismailov, S. V. Alieva, and V. A. Shibnev, Izv. Akad. Nauk TadzhSSR, No. 3, 97 (1978).Google Scholar
- 5.E. P. Rashevskaya, Yu. N. Chergadze, and V. A. Shibnev, 1st International Symposium on Peptide Chemistry [in Russian], Riga (1967), p. 86.Google Scholar