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Use of electron-spin-resonance spectroscopy for studying the conformational states of peptides gramicidin S

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Chemistry of Natural Compounds Aims and scope

Summary

1. A new method has been proposed for studying the conformational states of peptides in solutions which is based on a consideration of the ESR spectra of their spin-labeled derivatives.

2. The synthesis of derivatives of gramicidin S containing one and two iminoxyl radicals in the2Orn and7Orn side chains has been effected.

3. On the basis of an analysis of the ESR spectra of the compounds obtained at −196°C and 30–62°C, conformations of the side chains of modified ornithine residues in chloroform and ethanol have been proposed.

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Authors
  1. V. T. Ivanov
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  2. A. I. Miroshnikov
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  3. L. G. Snezhkova
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  4. Yu. A. Ovchinnikov
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  5. A. V. Kulikov
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  6. G. I. Likhtenshtein
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Additional information

M. M. Shemyakin Institute of the Chemistry of Natural Compounds, Academy of Sciences of the USSR. Branch of the Institute of Chemical Physics, Academy of Sciences of the USSR. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 91–98, January–February, 1973.

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Ivanov, V.T., Miroshnikov, A.I., Snezhkova, L.G. et al. Use of electron-spin-resonance spectroscopy for studying the conformational states of peptides gramicidin S. Chem Nat Compd 9, 82–87 (1973). https://doi.org/10.1007/BF00580899

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  • DOI: https://doi.org/10.1007/BF00580899

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