Summary
1. A number of fragments of angiotensin have been synthesized: asparaginylarginine, asparaginylarginylvaline, asparaginylarginylvalyltyrosine, asparaginylarginylvalyltyrosylvalylhistidine, valyltyrosylvalylhistidine, and prolylphenylalanine.
2. The fragments of the hormone differ both in their affinity for the receptor and in their internal activity and capacity for antagonizing or potentiating the action of angiotensin, which shows the existence of a definite functional organization of the molecule of the hormone.
3. The C-terminal amino acid residues of angiotensin include the bulk of the information necessary for the formation of a complex with the receptor, and the N-terminal acids that for the formation of the secondary signal.
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Literature cited
G. I. Chipens and O. S. Papsuevich, in: The Chemistry and Biology of Peptides [in Russian], Riga (1971), p. 5.
G. I. Chipens, in: The Chemistry and Biology of Peptides [in Russian], Riga (1971), p. 23.
J. M. van Rossum, Arch. Internat. Pharmacodyn.,143, 299 (1963).
A. P. Pavar and G. I. Chipens, Zh. Obshch. Khim.,41, 467 (1971).
D. Regoli and J. R. Vane, Brit. J. Pharmacol.,23, 351 (1964).
A. P. Pavar, P. Ya. Romanovskii, R. É. Vegner, G. I. Chipens, G. A. Inikhova, Yu. I. Indulen, Z. P. Auna, and V. E. Klusha, in: The Chemistry and Biology of Peptides [in Russian], Riga (1971), p. 48.
I. M. Hais and K. Macek, Paper Chromatography, 3rd ed., Academic Press, New York (1963).
F. Reindel and W. Hoppe, Chem. Ber.,87, 1103 (1954).
W. Rittel, D. Iselin, H. Kappeler, B. Riniker, and R. Schwyzer, Helv. Chim. Acta,40, 614 (1957).
R. Willstätter and E. Waldschmidt-Leitz, Ber.,54, 113 (1921).
R. L. M. Synge, Biochem. J.,42, 99 (1948).
R. H. Mazur, Can. J. Chem.,40, 1098 (1962).
M. Bodanszky and V. du Vigneaud, J. Amer. Chem. Soc.,81, 5688 (1959).
H. Schwarz, F. M. Bumpus, and I. H. Page, J. Amer. Chem. Soc.,79, 5697 (1957).
R. Schwyzer, B. Iselin, H. Kappeler, B. Riniker, W. Rittel, and H. Zuber, Helv. Chim. Acta,41, 1273 (1958).
R. Schwyzer, B. Iselin, H. Kappeler, and W. Rittel, Deutsche Auslegeschrift (German Provisional Patent Specification) 1,121,059 (to CIBA AG), Sept. 2 (1957).
Additional information
Institute of Organic Synthesis, Academy of Sciences of the Latvian SSR. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 77–83, January–February, 1973.
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Chipens, G.I., Pavar, A.P., Klusha, V.E. et al. Synthesis and investigation of the myotropic activity of some fragments of [5-valine]angiotensin. Chem Nat Compd 9, 69–74 (1973). https://doi.org/10.1007/BF00580896
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DOI: https://doi.org/10.1007/BF00580896