Summary
1. The 11α-hydroxylation of 16α, 17α-dimethylprogesterone has been effected by the strain ofRhizopus nigricans VNIKhFI-7 with a yield of hydroxy derivative of 61%.
2. In the transformation an unidentified dihydroxy compound is formed together with the 11α-hydroxy-16α, 17α-dimethylprogesterone.
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Additional information
S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemicals. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 46–48, January–February, 1973.
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Morozova, L.S., Gabinskaya, K.N. & Grinenko, G.S. Microbiological hydroxylation of 16α, 17α-dimethylprogesterone. Chem Nat Compd 9, 39–40 (1973). https://doi.org/10.1007/BF00580886
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DOI: https://doi.org/10.1007/BF00580886