Chemistry of Natural Compounds

, Volume 9, Issue 1, pp 39–40 | Cite as

Microbiological hydroxylation of 16α, 17α-dimethylprogesterone

  • L. S. Morozova
  • K. N. Gabinskaya
  • G. S. Grinenko


1. The 11α-hydroxylation of 16α, 17α-dimethylprogesterone has been effected by the strain ofRhizopus nigricans VNIKhFI-7 with a yield of hydroxy derivative of 61%.

2. In the transformation an unidentified dihydroxy compound is formed together with the 11α-hydroxy-16α, 17α-dimethylprogesterone.


Ammonium Nitrate Magnesium Sulfate Novi Proges Hydroxy Derivative 

Literature cited

  1. 1.
    V. I. Maksimov, F. A. Lur'i, and L. S. Morozova, Zh. Obshch. Khim.,33, 1666 (1963).Google Scholar
  2. 2.
    N. N. Suvorov, Med. Prom. SSSR, No. 3, 22 (1956).Google Scholar
  3. 3.
    A. G. Timofeeva, O. S. Madaeva, E. G. Gusakova, N. F. Kovylkina, N. I. Men'shova, and V. M. Novikova, Izv. Akad. Nauk SSSR, Ser. Biol., No. 6, 712 (1958).Google Scholar
  4. 4.
    W. P. Schneider, F. H. Lincoln, G. B. Spero, H. C. Muffay, and I. L. Thomson, J. Amer. Chem. Soc.,81, 3167 (1959).CrossRefGoogle Scholar
  5. 5.
    V. M. Ryzhkova, K. N. Gabinskaya, V. F. Shner, and N. N. Suvorov, Mikrobiol. Prom. SSSR, No. 2, 23 (1970).Google Scholar
  6. 6.
    N. Bhacca and D. Williams, Applications of NMR Spectroscopy in Organic Chemistry, Holden-Day, San Francisco (1964).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • L. S. Morozova
  • K. N. Gabinskaya
  • G. S. Grinenko

There are no affiliations available

Personalised recommendations