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Oximes and nitriles of cardenolides

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Abstract

The influence of the oximation of cardenolides and the production of 10-cyanocardenolides on their biological activity has been studied. The prefered conformation of strophanthidin 19-aldoxime has been established; it has chelate fragment as the result of the orientation in the same direction of the nitrogen atom of the oxime group and the hydroxy groups at C-3 and C-5.

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Authors
  1. I. F. Makarevich
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  2. M. V. Mokrouz
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  3. L. Ya. Topchii
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  4. I. P. Kovalev
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  5. V. E. Sokolova
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  6. Yu. I. Gubin
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  7. N. P. Bublik
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  8. V. A. Polyakov
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Additional information

All-Union Scientific-Research Institute of the Chemistry and Technology of Drugs, Khar'kov. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 608–612, September–October, 1983.

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Makarevich, I.F., Mokrouz, M.V., Topchii, L.Y. et al. Oximes and nitriles of cardenolides. Chem Nat Compd 19, 572–576 (1983). https://doi.org/10.1007/BF00576086

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  • DOI: https://doi.org/10.1007/BF00576086

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