Influence of transformed steroids on Na+,K+-dependent ATPase. II
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The relationship of the structures of a number of transformed steroids containing an open or closed 20-oxo-21a,17-tetrahydrofuran ring E and 23-oic acid derivatives with their Na+,K+-ATPase inhibiting activity has been studied. It has been found that steroids with branched side chains are more active than steroids with additional tetrahydropyran-4- and -2-one rings E. The most active in this series of 20-ketosteroids are those containing such polar groupings as diketone and epoxyethyl groupings. Steroids with a spirotetrahydrofuran ring at C(17) exhibit an activity greater than their pyranoside analogs.
KeywordsOxime Cardenolides Porcine Kidney Butenolide Tetrahydropyran
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- 1.N. M. Mirsalikhova, N. Sh. Pal'yants, and N. K. Abubakirov, Khim. Prir. Soedin., 95 (1978).Google Scholar
- 2.H. I. Portius and K. Repke, “Effects of steroids of different types on transport ATPase,” in: Symposium über Biochemisce Aspekte der Steroidforschung, Akad. Verlag, Berlin (1969), p. 179.Google Scholar
- 4.N. M. Mirsalikhova, F. T. Umarova, N. Sh. Pal'yants, and N. K. Abubakirov, Khim. Prir. Soedin., 188 (1976).Google Scholar
- 5.A. V. Kamernitskii, I. G. Reshetova, N. M. Mirsalikhova, and F. T. Umarova, Biokhimiya,47, No. 6, 957 (1982).Google Scholar