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Chemistry of Heterocyclic Compounds

, Volume 22, Issue 6, pp 625–629 | Cite as

Reactions of aromatic and heteroaromatic compounds carrying electron-acceptor substituents. 26. Acylaminomethylation of 2-acylthiophenes, 2-thiophenecarboxylic acid, and its esters

  • Ya. L. Gol'dfarb
  • A. P. Yakubov
  • L. I. Belen'kii
Article

Abstract

The reaction of 2-thiophene aldehyde, 2-acetylthiophene, 2-thiophene carboxylic acid, and its methyl ester with N-(hydroxymethyl)chloroacetamide in concentrated sulfuric acid yields a mixture of 4- and 5-(N-chloroacetylamino) methyl derivatives, the former being preferred.

Keywords

Methyl Ester Organic Chemistry Aldehyde Sulfuric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Ya. L. Gol'dfarb
    • 1
  • A. P. Yakubov
    • 1
  • L. I. Belen'kii
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRMoscow

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