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Bioglycans as immunomodulators

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Chemistry of Natural Compounds Aims and scope

Abstract

A review is given of facts relating to the search for and study of bioglycan immunomodulators which are polysaccharides and glycoconjugates of natural origin and possess the capacity for stimulating or inhibiting the immunity of Man and animals to various diseases. The structural-chemical characteristics and biological properties of the following classes of bioglycan immunomodulators are discussed: bacterial lipopolysaccharides and peptidoglycans of marine organisms. Particular attention is devoted to marine invertebrates as an important source of active bioglycan immunomodulators. On the basis of information that has been accumulated on this question, it is suggested that the capacity for producing bioglycans with pronounced immunostimulating activity is a common property of marine invertebrates.

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Literature cited

  1. É. V. Ermol'eva and G. E. Vaisberg, The Stimulation of the Nonspecific Resistance of the Organism and Bacterial Polysaccharides [in Russian], Moscow (1976).

  2. K. P. Balitskii and I. G. Veksler, The Reactivity of the Organism and the Chemotherapy of Tumors [in Russian], Kiev (1975).

  3. R. L. Whistler, A. A. Bushway, and P. P. Singh, Adv. Carbohydr. Chem. Biochem.,32, 235 (1976).

    Article  CAS  PubMed  Google Scholar 

  4. J. G. Holt (editor), The Shorter Bergey's Manual of Determinative Bacteriology, VIIIth ed., Williams and Wilkins, Baltimore (1977).

    Google Scholar 

  5. G. Drews, in: The Biology of the Blue-Green Algae, N. G. Carr and B. A. Whitton, eds., Blackwell Scientific Publications, Oxford (1973), pp. 96–116.

    Google Scholar 

  6. G. Weise, G. Drews, B. Jann, and K. Jann, Arch. Microbiol.,71, 89 (1970).

    CAS  Google Scholar 

  7. J. Weckesser, G. Drews, and H. Mayer, Annu. Rev. Microbiol.,33, 215 (1979).

    Article  CAS  PubMed  Google Scholar 

  8. L. V. Mikheyskaya [Mikheiskaya], R. G. Ovodova, and Yu. S. Ovodov, J. Bacteriol.,130, 1 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. L. V. Mikheiskaya, R. G. Ovodova, and Yu. S. Ovodov, Khim. Prir. Soedin., 146 (1981).

  10. W. Schmidt, G. Drews, J. Weckesser, I. Fromme, and D. Borowiak, Arch. Microbiol.,127, 209 (1980).

    Article  CAS  Google Scholar 

  11. W. Schmidt, G. Drews, J. Weckesser, and H. Mayer, Arch. Microbiol.,127, 217 (1980).

    Article  CAS  Google Scholar 

  12. J. Freund, Adv. Tubercul.,7, 130 (1956).

    Google Scholar 

  13. R. G. White, L. Berustock, R. G. Johns, and E. Lederer, Immunol.,1, 54 (1958).

    CAS  Google Scholar 

  14. I. Azuma, Y. Kishimoto, Y. Yamamura, and J. F. Petit, Jpn. J. Microbiol.,15, 193 (1971).

    Article  CAS  PubMed  Google Scholar 

  15. A. Adam, R. Ciorbaru, J. Petit, and E. Lederer, Proc. Natl. Acad. Sci. USA,69, 851 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. I. G. Bogdanov, Symposium on Antibiotics, Prague, Abstracts of Papers (1959), pp. 120–121.

  17. I. G. Bogdanov, P. G. Dalev, A. I. Gurevich, M. N. Kolosov, V. P. Mal'kova, L. A. Plemyannikova, and I. B. Sorokina, FEBS Lett.,57, 259 (1975).

    Article  CAS  PubMed  Google Scholar 

  18. G. H. Werner, R. Maral, F. Floch, and M. Joanne, Bull. Inst. Pasteur,75, 5 (1977).

    CAS  Google Scholar 

  19. A. R. Prevot, B. N. Halpern, G. Biozzi, C. Stiffel, D. Monton, J. C. Morard, I. Bouthillier, and C. Decrensefond, C. R. Acad. Sci. Paris, Ser. D,257, 13 (1963).

    CAS  Google Scholar 

  20. E. M. Hersch, G. M. Mavligit, J. U. Gutterman, and S. P. Richman, in: Cancer, E. F. Becker, ed., Vol. 6, Plenum, New York-Oxford (1977), pp. 425–532.

  21. E. Lederer, J. Med. Chem.,23, 819 (1980).

    Article  CAS  PubMed  Google Scholar 

  22. A. Adam, J.-F. Petit, P. Lefrancier, and E. Lederer, Mol. Cell. Biochem.,41, 27 (1981).

    Article  CAS  PubMed  Google Scholar 

  23. D. Miglioze-Samour and P. Jolles, Biochem. Biophys. Res. Commun.,66, 1316 (1972).

    Google Scholar 

  24. I. J. Hiu, Nature New Biol.,238, 241 (1972).

    Article  CAS  PubMed  Google Scholar 

  25. R. Ciorbaru, A. Adam, J. F. Petit, E. Lederer, C. Bona, and L. Chedid, Infect. Immun.,11, 257 (1975).

    CAS  PubMed  PubMed Central  Google Scholar 

  26. F. Ellouz, A. Adam, R. Ciorbaru, and E. Lederer, Biochem. Biophys. Res. Commun.,59, 1317 (1974).

    Article  CAS  PubMed  Google Scholar 

  27. S. Kotani, Y. Watanabe, F. Kinoshita, T. Shimono, I. Morisani, T. Shiba, S. Kusumoto, Y. Tarumi, and K. Ikenaka, Biken J.,18, 105 (1975).

    CAS  PubMed  Google Scholar 

  28. F. Audibert, L. Chedid, P. Lefrancier, and J. Choay, Cell. Immunol.,21, 243 (1976).

    Article  CAS  PubMed  Google Scholar 

  29. B. Heyner and E. T. Rietschel, Microbiology, 344 (1977).

  30. A. Catero, S. B. Azevedo, A. E. Arêaleão, et al., Acta Univ. Intern. Contra Cancrum.,7, 448 (1951).

    Google Scholar 

  31. Z. T. Mankowski, Proc. Soc. Appl. Bacteriol.,83, 25 (1955).

    Google Scholar 

  32. Z. Mankowski, I. C. Diller, and M. E. Fisher, Cancer Res.,17, 382 (1957).

    CAS  PubMed  Google Scholar 

  33. E. H. Lucas, R. L. Ringer, et al., Antibiot. Chemotherapy,7, 1 (1957).

    CAS  Google Scholar 

  34. G. Chihara, Y. Maeda, J. Hamuro, T. Sasaki, and F. Fukuoka, Nature (London),222, 687 (1969).

    Article  CAS  PubMed  Google Scholar 

  35. G. Chihara, J. Hamuro, Y. Y. Maeda, Y. Arai, and F. Fukuoka, Cancer Res.,30, 2776 (1970).

    CAS  PubMed  Google Scholar 

  36. Y. Y. Maeda and G. Chihara, Nature (London),229, 634 (1971).

    Article  CAS  PubMed  Google Scholar 

  37. Y. Y. Maeda, J. Hamuro, Y. O. Yamada, K. Ishimura, and G. Chihara, in: Immunopotentiation. Ciba Foundation Symposium No. 18, Elsevier, Excerpta Medica, Amsterdam (1973), pp. 257–286.

    Google Scholar 

  38. G. Dennert and D. Tucker, J. Natl. Cancer Inst.,51, 1727 (1973).

    Article  CAS  PubMed  Google Scholar 

  39. J. Hamuro, M. Rollingholf, and H. Wagner, Cancer Res.,38, 3080 (1978).

    CAS  PubMed  Google Scholar 

  40. T. Sasaki, N. Takasuka, G. Chihara, and Y. Y. Maeda, Gann,67, 191 (1976).

    CAS  PubMed  Google Scholar 

  41. T. Sasaki and N. Takasuka, Carbohydr. Res.,47, 99 (1976).

    Article  CAS  PubMed  Google Scholar 

  42. M. P. Champion, C. R. Acad. Sci. Paris,75, 1526 (1872).

    Google Scholar 

  43. E. Fisher, Hedwigia,30, 61 (1891).

    Google Scholar 

  44. S. A. Warsi and W. J. Whelan, Chem. Ind. (London), 1573 (1957).

  45. G. C. Hoffmann, B. W. Simson, and T. E. Timell, Carbohydr. Res.,20, 185 (1971).

    Article  CAS  PubMed  Google Scholar 

  46. H. Saito, A. Misaki, and T. Harada, Agric. Biol. Chem.,32, 1261 (1968).

    Article  CAS  Google Scholar 

  47. G. Chihara, J. Hamuro, Y. Y. Maeda, Y. Arai, and F. Fukuoka, Nature (London),225, 943 (1970).

    Article  CAS  PubMed  Google Scholar 

  48. Y. Y. Maeda, J. Hamuro, and G. Chihara, Int. J. Cancer,8, 41 (1971).

    Article  CAS  PubMed  Google Scholar 

  49. J. Hamuro, Y. Yamashita, Y. Ohsaka, Y. Y. Maeda, and G. Chihara, Nature (London),233, 486 (1971).

    Article  CAS  PubMed  Google Scholar 

  50. H. Ito, J. Fujii, S. Naruse, M. Sugiura, and T. Miyazaki, Mie Med. J.,22, 103 (1972).

    CAS  Google Scholar 

  51. T. Miyazaki, T. Yadomae, M. Sugiura, H. Ito, K. Fujii, S. Naruse, and M. Kunihisa, Chem. Pharm. Bull.,22, 1739 (1974).

    Article  CAS  PubMed  Google Scholar 

  52. H. Ito, S. Naruse, and M. Sugiura, Folia Pharmacol. Jpn.,72, 77 (1976).

    Article  CAS  Google Scholar 

  53. H. Ito, M. Sugiura, and M. Miyazaki, Chem. Pharm. Bull.,24, 2575 (1976).

    Article  CAS  PubMed  Google Scholar 

  54. T. Miyazaki and N. Oikawa, Chem. Pharm. Bull.,21, 2545 (1973).

    Article  CAS  Google Scholar 

  55. T. Miyazaki, N. Oikawa, H. Yamada, and T. Yadomae, Carbohydr. Res.,65, 235 (1978).

    Article  CAS  PubMed  Google Scholar 

  56. T. Miyazaki, N. Oikawa, T. Yadomae, H. Yamada, Y. Yamada, Hong-Yen Hsu, and H. Ito, Carbohydr. Res.,69, 165 (1979).

    Article  CAS  PubMed  Google Scholar 

  57. Y. Ueno, Y. Okamoto, R. Yamauchi, and K. Kato, Carbohydr. Res.,101, 160 (1982).

    Article  CAS  PubMed  Google Scholar 

  58. T. Sasaki, Y. Arai, T. Ikekawa, G. Chihara, and F. Fukuoka, Chem. Pharm. Bull.,19, 821 (1971).

    Article  CAS  PubMed  Google Scholar 

  59. T. Usui, Y. Iwasaki, K. Hayashi, T. Mazuno, M. Tanaka, K. Shinkai, and M. Arakawa, Agric. Biol. Chem.,45, 323 (1981).

    CAS  Google Scholar 

  60. N. Komatsu, S. Okubo, S. Kikumoto, K. Kimura, G. Saito, and S. Sakai, Gann,60, 137 (1969).

    CAS  PubMed  Google Scholar 

  61. N. Komatsu, S. Okubo, and S. Kikumoto, J. Antibiot. (Tokyo) Ser. B.,23, 157 (1970); Chem. Abstr.73, 129539 (1970).

  62. S. Kikumoto, T. Miyama, S. Yoshizumi, S. Fujimoto, and K. Kimura, Nippon Nogei Kagaku Kaishi,44, 337 (1970); Chem. Abstr.,74, 61776g (1971).

    Article  CAS  Google Scholar 

  63. K. Tabata, W. Ito, T. Kojima, S. Kawabata, and A. Misaki, Carbohydr. Res.,89, 121 (1981).

    Article  CAS  PubMed  Google Scholar 

  64. T. Sato, T. Norisuye, and H. Fujita, Carbohydr. Res.,95, 195 (1981).

    Article  CAS  Google Scholar 

  65. J. Johnson, S. Kirkwood, A. Misaki, T. E. Nelson, J. V. Scaletti, and F. Smith, Chem. Ind. (London), 820 (1963).

  66. P. P. Singh, R. L. Whistler, R. Tokuzen, and W. Nakahara, Carbohydr. Res.,37, 245 (1974).

    Article  CAS  PubMed  Google Scholar 

  67. S. Sakai, C. Takada, T. Kamasuka, K. Monioki, and J. Sugayama, Gann,59, 507 (1968).

    CAS  PubMed  Google Scholar 

  68. S. A. Archer, J. R. Clamp, and O. Migliore, J. Gen. Microbiol.,102, 157 (1977).

    Article  CAS  Google Scholar 

  69. Y. Sone, M. Kakuta, and A. Misaki, Agric. Biol. Chem.,42, 417 (1978).

    CAS  Google Scholar 

  70. A. Misaki, M. Kakuta, T. Sasaki, M. Tanaka, and H. Miyaji, Carbohydr. Res.,92, 115 (1981).

    Article  CAS  PubMed  Google Scholar 

  71. T. Sasaki, N. Abiko, Y. Sugino, and K. Nitta, Cancer Res.,38, 379 (1978).

    CAS  PubMed  Google Scholar 

  72. T. Sasaki, N. Abiko, K. Nitta, N. Takasuka, and Y. Sugino, Eur. J. Cancer,15, 211 (1979).

    Article  CAS  PubMed  Google Scholar 

  73. N. I. Sukhareva-Nemakova, V. I. Brusovanik, N. M. Kalenik, and A. B. Silaev, in: Urgent Questions of Modern Oncology [in Russian], Moscow, No. 4 (1975), p. 220.

  74. S. Ukai, K. Hirose, T. Kiho, C. Hara, T. Irikura, T. Kanechika, and Y. Hasegawa, Chem. Pharm. Bull.,20, 2293 (1972).

    Article  CAS  PubMed  Google Scholar 

  75. S. Ukai, K. Hirose, T. Kiho, and C. Hara, Chem. Pharm. Bull.,22, 1102 (1974).

    Article  CAS  Google Scholar 

  76. S. Ukai, K. Hirose, T. Kiho, and C. Hara, Chem. Pharm. Bull.,25, 338 (1977).

    Article  CAS  Google Scholar 

  77. T. Kiho, C. Hara, and S. Ukai, Chem. Pharm. Bull.,29, 225 (1981).

    Article  CAS  Google Scholar 

  78. G. Chihara and Kobunshi, High Poly. Jpn.,26, 117 (1977).

    CAS  Google Scholar 

  79. A. Kakinuma, T. Asano, H. Torii, and Y. Sugino, Biochem. Biophys. Res. Commun.,101, 434 (1981).

    Article  CAS  PubMed  Google Scholar 

  80. F. Fukuoka, M. Nakanishi, S. Shibata, Y. Nishikawa, T. Takeda, and M. Tanaka, Gann,59, 421 (1968).

    CAS  PubMed  Google Scholar 

  81. Y. Nishikawa, T. Takeda, S. Shibata, and F. Fukuoka, Chem. Pharm. Bull.,17, 1910 (1969).

    Article  CAS  PubMed  Google Scholar 

  82. M. Takeda, M. Funatsu, S. Shibata, and F. Fukuoka, Chem. Pharm. Bull.,20, 2445 (1972).

    Article  CAS  PubMed  Google Scholar 

  83. I. Yokota, S. Shibata, and H. Saito, Carbohydr. Res.,69, 252 (1979).

    Article  CAS  Google Scholar 

  84. K. Takahashi, T. Takeda, S. Shibata, M. Inomata, and F. Fukuoka, Chem. Pharm. Bull.,22, 404 (1974).

    Article  CAS  Google Scholar 

  85. Y. Nishikawa, K. Ohai, K. Takahashi, G. Kurono, F. Fukuoka, and M. Emori, Chem. Pharm. Bull.,22, 2692 (1974).

    Article  CAS  PubMed  Google Scholar 

  86. Y. Nishikawa, K. Yoshimoto, R. Horiuchi, K. Michishita, M. Okabe, and F. Fukuoka, Chem. Pharm. Bull.,27, 2065 (1979).

    Article  CAS  PubMed  Google Scholar 

  87. K. Takahashi, T. Kon, I. Yokota, and S. Shibata, Carbohydr. Res.,89, 166 (1981).

    Article  CAS  Google Scholar 

  88. A. A. Zeidaka and Kh. F. Bass-Sharkhar, Zh. Prikl. Khim. Biokhim. Mikrobiol.,13, 359 (1977).

    CAS  Google Scholar 

  89. Kh. F. Bass-Sharkhan and A. A. Zeidaka, in: New Immunoregulating Drugs and Immunological Methods [in Russian], Riga (1978), p. 9.

  90. Y. Nishikawa and H. Ohino, Chem. Pharm. Bull.,29, 3407 (1981).

    Article  CAS  PubMed  Google Scholar 

  91. L. Pillemer and E. Ecker, J. Biol. Chem.,137, 139 (1941).

    CAS  Google Scholar 

  92. L. Pillemer et al., J. Immunol.,71, 331 (1953).

    CAS  PubMed  Google Scholar 

  93. D. Rowley, Lancet,1, 232 (1955).

    Article  Google Scholar 

  94. S. M. Navashin, I. P. Fomina, and T. G. Terent'eva, Dokl. Akad. Nauk SSSR.158, 981 (1964).

    CAS  Google Scholar 

  95. W. T. Bradner, D. A. Clarke, and C. C. Stock, Cancer Res.,18, 347 (1958).

    CAS  PubMed  Google Scholar 

  96. J. S. Kiser, H. Lindh, and G. C. DeMello, Ann. N.Y. Acad. Sci.,66, 312 (1956).

    Article  CAS  Google Scholar 

  97. G. Mathé and J. Bernard, C. R. Acad. Sci. Paris,150, 1768 (1956).

    Google Scholar 

  98. H. F. Oettgen and W. W. Gallmeier, Dtsch. Med. Wschr.,93, 1157 (1968).

    Article  CAS  PubMed  Google Scholar 

  99. I. C. Diller, Z. T. Mankowski, and M. E. Fisher, Cancer Res.,23, 201 (1963).

    CAS  PubMed  Google Scholar 

  100. K. Pfordte, Z. Naturforsch.,216, 56 (1966).

    Article  Google Scholar 

  101. Kh. M. Veksler, Zh. U. Timoshenko, A. I. Keish, I. M. Remez, V. A. Sevast'yanova, and O. V. Popova, in: Nonspecific Stimulators of the Reactivity of the Organism and Their Use in Oncology [in Russian], Riga (1977), p. 104.

  102. M. A. Kashkina and N. P. Elikov, Zh. Mikrobiol., Épidemiol. Immunobiol., No. 5, 86 (1977).

  103. V. É. Liepa, S. A. Avertsev, and Kh. F. Bass-Sharkhan, in: Immunological Homeostasis and Immunoregulating Therapy [in Russian], Riga (1979), p. 133.

  104. I. G. Veksler, Byull. Éksp. Biol. Med., No. 8, 64 (1980).

  105. N. R. Di Luzio, Adv. Exp. Med. Bull.,73, 412 (1976).

    Google Scholar 

  106. N. R. Di Luzio, R. McNamee, E. Jones, J. A. Cook, and E. O. Hoffman, in: The Macrophages in Neoplasia, M. A. Fink, ed., Academic Press, New York (1976), p. 181.

    Chapter  Google Scholar 

  107. N. R. Di Luzio and J. C. Pisano, J. Reticuloendothel. Soc.,7, 731 (1970).

    PubMed  Google Scholar 

  108. A. F. Blyuger, Kh. M. Veksler, Ya. D. Keish, P. M. S"yakete, O. V. Popova, Kh. F. Bass-Sharkhan, and G. K. Zakenfel'd, in: New Immunoregulating Drugs and Immunological Methods [in Russian], Riga (1978), p. 5.

  109. J. A. Cook, D. Taylor, C. Cohen, E. O. Hoffman, J. Rodriguez, V. Malshet, and N. R. Di Luzio, J. Reticuloendothel. Soc.,22, 21 (1977).

    CAS  PubMed  Google Scholar 

  110. H. Mashiba, M. Gojobori, and K. Matsunaga, Gann,68, 703 (1977).

    CAS  PubMed  Google Scholar 

  111. D. H. Northcote, Pure Appl. Chem.,7, 669 (1963).

    Article  CAS  Google Scholar 

  112. C. E. Ballou and W. C. Raschke, Science,184, 127 (1974).

    Article  CAS  PubMed  Google Scholar 

  113. G. H. Fleet and D. J. Manners, J. Gen. Microbiol.,94, 180 (1976).

    Article  CAS  PubMed  Google Scholar 

  114. S. Suzuki, M. Suzuki, H. Hatsukaiwa, H. Sunayama, T. Suzuki, M. Uchiyama, F. Fukuoka, M. Nakonishi, and S. Akiya, Gann,60, 273 (1969); S. Suzuki, H. Natsukaiwa, H. Sunayama, M. Uchiyama, F. Fukuoka, M. Nakanishi, and S. Akiya, Gann,60, 65 (1969).

    CAS  PubMed  Google Scholar 

  115. S. J. Riggi and N. R. Di Luzio, Fed. Proc.,20, 265 (1961).

    Google Scholar 

  116. I. C. Diller, M. E. Fisher, and D. Gable, Proc. Soc. Exp. Biol. Med.,117, 107 (1964).

    Article  CAS  PubMed  Google Scholar 

  117. D. J. Bell and D. H. Northcote, J. Chem. Soc., 1944 (1950).

  118. R. J. Yu, C. T. Bishop, F. P. Cooper, F. Blank, and H. F. Hasenclever, Can. J. Chem.,45, 2264 (1967).

    Article  CAS  Google Scholar 

  119. D. J. Manners, A. J. Masson, and J. C. Patterson, J. Gen. Microbiol.,80, 411 (1974).

    Article  CAS  PubMed  Google Scholar 

  120. D. J. Manners and M. T. Meyer, Carbohydr. Res.,57, 189 (1977).

    Article  CAS  Google Scholar 

  121. W. C. Raschke, K. A. Kern, C. Antalis, and C. E. Ballou, J. Biol. Chem.,248, 4660 (1973).

    CAS  PubMed  Google Scholar 

  122. C. E. Ballou, K. A. Kern, and W. C. Raschke, J. Biol. Chem.,248, 4667 (1973).

    CAS  PubMed  Google Scholar 

  123. T. Matsumoto, M. Takanohashi, Y. Okubo, M. Suzuki, and S. Suzuki, Carbohydr. Res.,83, 363 (1980).

    Article  CAS  PubMed  Google Scholar 

  124. P. A. J. Gorin and J. F. T. Spencer, Adv. Carbohydr. Chem.,23, 367 (1968).

    CAS  Google Scholar 

  125. N. P. Elinov, “The antigenic determinants of yeasts,” in: Proceedings of the 4th International Symposium on Yeasts, Vienna, Part II (1974), pp. 35–48.

  126. O. G. Sakandelidze and R. E. Kipiani, Biologically Active Substances of Hydrobionts — A New Source of Drugs [in Russian]. Kishinev (1979).

  127. G. R. Pettit, Biosynthetic Products for Cancer Chemotherapy, Vol. 1, Plenum Press, New York-London (1977), pp. 165–175.

    Book  Google Scholar 

  128. C. P. Li, A. Goldin, and J. L. Hartwell, Cancer Chemother. Rep., Part 2,4, 97–129 (1974).

    CAS  Google Scholar 

  129. M. R. Schmeer, Science,144, 413–414 (1964).

    Article  CAS  PubMed  Google Scholar 

  130. A. Hegyeli, Science,146, 77–79 (1964).

    Article  CAS  PubMed  Google Scholar 

  131. A. C. Schmeer, Physiol. Chem. Phys.,11, 415–424 (1979); Fed. Proc.,37, 317–323 (1978).

    CAS  PubMed  Google Scholar 

  132. Yu. S. Ovodov, R. G. Gorshkova, S. V. Tomshich, and M. N. Adamenko, Comp. Biochem. Physiol.,29, 1093–1098 (1969).

    Article  CAS  Google Scholar 

  133. N. A. C. Allison, J. S. Warington, and M. Birbeck, J. Exp. Med.,124, 141–149 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  134. G. E. Davies, Immunology,8, 291–295 (1965).

    CAS  PubMed  PubMed Central  Google Scholar 

  135. J. A. Bash and J. R. Vago, J. Reticuloendothel. Soc.,28, 213–221 (1980).

    CAS  PubMed  Google Scholar 

  136. V. M. Rumjanek, S. R. Watson, and V. S. Slijivic, Immunology,33, 423–432 (1977).

    CAS  PubMed  PubMed Central  Google Scholar 

  137. A. W. Thomson, Biomedicine,28, 148–160 (1978).

    CAS  PubMed  Google Scholar 

  138. A. W. Thomson, E. F. Fowler, V. S. Slijivic, and L. Brent, Lancet, 1034 (1980).

  139. A. W. Thomson, L. Brent, and E. F. Fowler, Lancet, 671 (1981).

  140. P. C. Quan, J. P. Kolb, and G. Lespinats, Cell. Immunol.,37, 1–9 (1978).

    Article  CAS  PubMed  Google Scholar 

  141. J. P. Kolb, P. C. Quan, M. F. Poupon, and C. Desaymard, Cell. Immunol.,57, 348–360 (1981).

    Article  CAS  PubMed  Google Scholar 

  142. T. Sasaki, N. Takasuka, and N. Abiko, J. Natl. Cancer Inst.,60, 1499–1500 (1978).

    Article  CAS  PubMed  Google Scholar 

  143. Yu. S. Ovodov, R. G. Ovodova, and Yu. N. Loenko, The Chemistry and Biochemistry of Carbohydrates [in Russian], Pushchino (1982), pp. 4–5.

  144. V. I. Molchanova, R. G. Ovodova, I. Perera, and Yu. S. Ovodov, Khim. Prir. Soedin., 677 (1982).

  145. T. S. Zaporozhets, R. G. Ovodova, Yu. N. Loenko, and N. N. Besednova, Zh. Mikrobiol. Épidemiol. Immunobiol., No. 2, 106–107 (1981).

  146. T. S. Zaporozhets, Yu. N. Loenko, R. G. Ovodova, N. F. Timchenko, N. G. Prokof'eva, and N. N. Besednova, Antibiotiki, No. 6, 460–465 (1981).

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  1. Yu. S. Ovodov
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Review lecture at the VIIth All-Union Conference on the Chemistry and Biochemistry of Carbohydrates, Pushchino-on-Oka, 1982.

Pacific Ocean Institute of Bioorganic Chemistry, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 675–694, November–December, 1983.

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Ovodov, Y.S., Ovodova, R.G. & Loenko, Y.N. Bioglycans as immunomodulators. Chem Nat Compd 19, 639–657 (1983). https://doi.org/10.1007/BF00575160

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