Abstract
Heating papaverine with chloral hydrate and benzoyl chloride formed products of the replacement of the hydrogen at the 15-C atom of papaverine: 15-(β-trichloro-α-hydroxyethyl)papaverine and 15-benzoylpapaverine. In reactions with monochloro- and trichloroacetic acids under mild conditions in the cold, salts at the nitrogen atom were formed: the monochloroacetate and the trichloroacetate. The products were characterized by the results of TLC (type KSK silica gel fixed with gypsum), elementary analyses, and IR and PMR spectroscopy.
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Additional information
V. I. Nikitin Institute of Chemistry, Academy of Sciences of the Tadzhik SSR, Dushanbe. Translated from Khimiya Prirodnykh Soedinenii, No. 4, pp. 500–502, July–August, 1984.
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Degtyarev, V.A., Sadykov, Y.D., Kurbanov, M. et al. Some papaverine derivatives. Chem Nat Compd 20, 472–474 (1984). https://doi.org/10.1007/BF00574337
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DOI: https://doi.org/10.1007/BF00574337