Some papaverine derivatives
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Heating papaverine with chloral hydrate and benzoyl chloride formed products of the replacement of the hydrogen at the 15-C atom of papaverine: 15-(β-trichloro-α-hydroxyethyl)papaverine and 15-benzoylpapaverine. In reactions with monochloro- and trichloroacetic acids under mild conditions in the cold, salts at the nitrogen atom were formed: the monochloroacetate and the trichloroacetate. The products were characterized by the results of TLC (type KSK silica gel fixed with gypsum), elementary analyses, and IR and PMR spectroscopy.
KeywordsHydroxyethyl Chloral Hydrate Papaverine Benzoyl Chloride Methyl Acetate
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