Kinetics of the acetylation of e- and α-hydroxyls in cardenolides
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Kinetic investigations of the rate of acetylation of e- anda-hydroxy groups in cardenolides have been carried out. It has been shown that equatorial hydroxyls in aglycones acetylate more than four times as fast as axial hydroxyls.
On the basis of the acetylation of reaction, a simple method has been proposed for determining the conformations of secondary OH groups in steroid compounds.
The possibility has been shown of using the acetylation reaction for introducing protective groups on e-hydroxyls.
KeywordsCaustic Soda Cardenolides Steroid Compound Strophanthidin Acetylation Reaction
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