Conclusions
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1.
Kinetic investigations of the rate of acetylation of e- anda-hydroxy groups in cardenolides have been carried out. It has been shown that equatorial hydroxyls in aglycones acetylate more than four times as fast as axial hydroxyls.
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2.
On the basis of the acetylation of reaction, a simple method has been proposed for determining the conformations of secondary OH groups in steroid compounds.
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3.
The possibility has been shown of using the acetylation reaction for introducing protective groups on e-hydroxyls.
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Khimiya Prirodnykh Soedinenii, Vol. 4, No. 4, pp. 221–225, 1968
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Makarevich, I.F. Kinetics of the acetylation of e- and α-hydroxyls in cardenolides. Chem Nat Compd 4, 190–192 (1968). https://doi.org/10.1007/BF00571132
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DOI: https://doi.org/10.1007/BF00571132