Chemistry of Natural Compounds

, Volume 4, Issue 4, pp 190–192 | Cite as

Kinetics of the acetylation of e- and α-hydroxyls in cardenolides

  • I. F. Makarevich
Article

Conclusions

  1. 1.

    Kinetic investigations of the rate of acetylation of e- anda-hydroxy groups in cardenolides have been carried out. It has been shown that equatorial hydroxyls in aglycones acetylate more than four times as fast as axial hydroxyls.

     
  2. 2.

    On the basis of the acetylation of reaction, a simple method has been proposed for determining the conformations of secondary OH groups in steroid compounds.

     
  3. 3.

    The possibility has been shown of using the acetylation reaction for introducing protective groups on e-hydroxyls.

     

Keywords

Caustic Soda Cardenolides Steroid Compound Strophanthidin Acetylation Reaction 

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References

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    L. Fieser and M. Fieser, Steroids [Russian translation], Moscow, 1964.Google Scholar
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    Fuchs, M. Wichtl, and H. Jachs, Archiv der Pharmazie, 291, no. 4, 193, 1958.CrossRefGoogle Scholar
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    I. P. Kovalev and V. T. Chernobai, KhPS [Chemistry of Natural Compounds], 2, 179, 1966.CrossRefGoogle Scholar
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    I. F. Makarevich, KhPS [Chemistry of Natural Compounds], 3, 217, 1967.Google Scholar
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    I. F. Makarevich, Khim. farm. zh., no. 6, 29, 1967.Google Scholar

Copyright information

© The Faraday Press, Inc. 1971

Authors and Affiliations

  • I. F. Makarevich
    • 1
  1. 1.Khar'kov Chemical and Pharmaceutical Scientific-Research InstituteUSSR

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