Abstract
To evaluate the possibility that platelet dysfunctions contribute to the cardiovascular risk of microalbuminuric insulin-dependent diabetic (IDD) patients, we have measured beta-thromboglobulin (BTG) and platelet factor 4 (PF4) in 74 IDD patients with different degrees of albuminuria (8 macro-, 36 micro- and 30 normoalbuminuric) and in 30 non-diabetic control subjects. BTG values (20.4±1.5 SEM in normo-, 22.2±1.2 in micro-, 101.1±2.9 in macroalbuminuric patients and 21.8±1.1 IU/ml in control subjects) were significantly higher (P<0.001) in the macroalbuminuric patients, but similar among the other groups. These results suggest that platelet hyperactivation is not present in the microalbuminuric stage of diabetic nephropathy, only in overt nephropathy.
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Gruden, G., Cavallo-Perin, P., Romagnoli, R. et al. Plasma beta-thromboglobulin and platelet factor 4 are not increased in insulin-dependent diabetic patients with microalbuminuria. Acta Diabetol 31, 130–132 (1994). https://doi.org/10.1007/BF00570365
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DOI: https://doi.org/10.1007/BF00570365