Chemistry of Natural Compounds

, Volume 9, Issue 4, pp 485–491 | Cite as

Synthesis of some arginine- and lysine-containing fragments of peptide hormones and investigation of their biological activity

  • R. É. Vegner
  • G. I. Chipens
  • V. E. Klusha
  • Z. P. Auna


1. The tripeptides of the ACTH sequence [18–20], the angiotensin sequence [1–3], the vasopressin sequence [7–9], the bradykinin sequence [1–3], the β-MSH sequence [20–22], and the fibrinopeptide B sequence [12–14] have been synthesized.

2. It has been shown that these compounds possess considerable myotropic activity in vitro experiments on isolated organs of the smooth musculature, but lack the specificity of the action of the natural hormones.


Hydrogen Chloride Benzyl Ester Ammonium Acetate Solution Common Fragment Palladium Black 


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Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • R. É. Vegner
  • G. I. Chipens
  • V. E. Klusha
  • Z. P. Auna

There are no affiliations available

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