Conclusions
1. By means of the NMR method it has been shown that tetracycline hydrochloride undergoes rapid epimerization in pyridine solution.
2. The temperature dependence of the constant of the equilibrium TC ⇆ ETC has been studied and the thermodynamic characteristics of this equilibrium have been calculated.
3. The scheme of the transformations of tetracycline hydrochloride leading to the formation of the epimer has been put forward.
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Additional information
All-Union Scientific-Research Institute of Antibiotics. All-Union Scientific-Research Institute of Medicinal Plants. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 67–72, January–February, 1974.
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Sheberstova, N.V., Perel'son, M.E. & Kuzovkov, A.D. Study of the epimerization of tetracycline by the NMR method. Chem Nat Compd 10, 61–65 (1974). https://doi.org/10.1007/BF00568224
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DOI: https://doi.org/10.1007/BF00568224