Advertisement

Chemistry of Natural Compounds

, Volume 4, Issue 2, pp 102–104 | Cite as

Synthesis of a biologically active amide of the C-terminal tetrapeptide fragment of gastrin on a resin

  • L. A. Shchukina
  • L. Yu. Sklyarov
  • V. I. Gorbunov
Article

Summary

The solid-phase synthesis of the biologically active fragment of gastrin BOC-L-Try-L-Met-L-Asp-L-PheNH2 has been carried out on a resin obtained by the copolymerization of styrene with divinyl benzene. The swellability of the resin used corresponded to a content of 0.5–0.8% of divinylbenzene in it.

Keywords

Benzoyl Peroxide Stannic Chloride Benzyl Ester Triethylamine Hydrochloride Chloromethyl Ether 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    H.I. Tracy and R.A. Gregory, Nat., 204, 935, 1964.CrossRefGoogle Scholar
  2. 2.
    J.S. Morley, H.I. Tracy, and R.A. Gregory, Nat., 207, 1357, 1965.CrossRefGoogle Scholar
  3. 3.
    I.M. Davey, A. H. Laird, and J.S. Morley, J. Chem. Soc., 555, 1966.Google Scholar
  4. 4.
    R.B. Merrifield, Biochem., 3, 1385, 1964.CrossRefGoogle Scholar
  5. 5.
    E.B. Trostyanskaya, A.S. Gevolina, and F.A. Naumova, Vysokomol. soed., 5, no. 8, 1240, 1963.Google Scholar
  6. 6.
    L.A. Shcukina and L.Yu. Sklyarov, KhPS [Chemistry of Natural Compounds],2, 200, 1966.CrossRefGoogle Scholar
  7. 7.
    W. Ressler and B. Iselin, Hevl. Chim. Acta, 49, 1330, 1966.CrossRefGoogle Scholar
  8. 8.
    G.W. Anderson, I.E. Zimmerman, and F.M. Callahan, J. Am. Chem. Soc.,86, 1839, 1964.CrossRefGoogle Scholar
  9. 9.
    G.W. Anderson and A.S. McGregor, J. Am. Chem. Soc., 79, 6180, 1957.CrossRefGoogle Scholar
  10. 10.
    E. Wünsch and A. Zwick, Z. physiol. Chem., 328, 235, 1962.CrossRefGoogle Scholar
  11. 11.
    L. Zervas, D. Borovas, and E. Gazis, J. Am. Chem. Soc., 85, 3660, 1963.CrossRefGoogle Scholar
  12. 12.
    R. Schwyzer, P. Sieber, and H. Rappeler, Helv. Chim. Acta, 42, 2622, 1959.CrossRefGoogle Scholar

Copyright information

© The Faraday Press, Inc. 1969

Authors and Affiliations

  • L. A. Shchukina
    • 1
  • L. Yu. Sklyarov
    • 1
  • V. I. Gorbunov
    • 1
  1. 1.Institute of the Chemistry of Natural Compounds, AS USSRUSSR

Personalised recommendations