Summary
The reaction of chymotrypsin with a number of modified analogs of the specific inhibitor of chymotrypsin L-1-tosylamido-2-phenylethyl chloromethyl ketone has been studied; the compounds investigated were D-1-tosylamido-2-phenethyl chloromethyl ketone, phenethyl chloromethyl ketone (PECK), and benzylethyl chloromethyl ketone (BCMK).
It has been shown that D-TAPK does not possess inhibiting activity. The inhibiting capacity of PECK is considerably reduced. A simultaneous decrease in the length of the carbon chain and the elimination of the tosylamino group (BCMK) practically destroys the inhibiting action of the reagent.
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Khimiya Prirodnykh Soedinenii, Vol. 4, No. 2, pp. 116–120, 1968
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Botvinik, M.M., Novodarova, G.N. & D'yakov, V.L. A study of the reactions of the chemical modification of chymotrypsin. I. Chem Nat Compd 4, 99–101 (1968). https://doi.org/10.1007/BF00568021
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DOI: https://doi.org/10.1007/BF00568021