Conclusions
The synthesis of the following analogs of the A17–21 fragment of insulin has been effected by the solid-phase method: the hydrobromides of H-Glu-Ala-Tyr-Cys(Bzl)-Asn-OH and of H-Glu-Ala-Phe-Cys(Bzl)-Asn-OH, and also BOC-Ala-Asn-Tyr(Bzl)-Cys(Bzl)-Asn-OH. The possibility of adding to a chloromethylated polymeric support a protected dipeptide with the composition BOC-Cys(Bzl)-Asn-OH has been shown.
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Literature cited
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Additional information
M. V. Lomonosov Moscow State University. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 799–803, November–December, 1971.
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Korshunova, G.A., Mishin, G.P., Semiletov, Y.A. et al. Solid-phase synthesis of analogs of the A17–21 fragment of insulin. Chem Nat Compd 7, 771–773 (1971). https://doi.org/10.1007/BF00567935
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DOI: https://doi.org/10.1007/BF00567935