Conclusions
1. New methods for the O-aminoacylation of dextran (“polyglucin”) with mixed anhydrides of N-protected amino acids with benzenesulfonyl chloride, tosyl chloride, ethyl chloroformate, and phosphorus oxychloride have been proposed.
2. By these methods, and also by the method developed previously using dicyclohexylcarbodiimide, esters of dextran with N-tosylglycine, N-o-nitrophenylsulfenylglycine, N-benzyloxycarbonyl-ε-aminoenanthic acid, N-tert-butoxycarbonyl-L-alanine, N-tert-butoxycarbonyl-L-phenylalanine, N-o-nitrophenylsulfenyl-L-phenylalanine, and N-o-nitrophenylsulfenyl-L-valine have been synthesized.
3. Methods for eliminating the o-nitrophenylsulfenyl group from esters of NPS amino acids with dextran by means of thiophenol or a mixture of Na2S2O3 + KI have been recommended.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
A. E. Vasil'ev, A. B. Livshits, G. Ya. Rozenberg, and N. K. Kochetkov, Khim. Prirodn. Soedin.,5, 525 (1969).
N. K. Kochetkov, A. A. Khachatur'yan, A. E. Vasil'ev, and G. Ya. Rozenberg, Khim. Prirodn. Soedin.,5, 427 (1969).
Additional information
For Communication II, see [1].
Central Order of Lenin Institute of Hematology and Blood Transfusion. Translated from Khimiya Prirodnykh Soedinenii, No. 6, pp. 698–704, November–December, 1971.
Rights and permissions
About this article
Cite this article
Vasil'ev, A.E., Khachatur'yan, A.A. & Rozenberg, G.Y. Dextran derivatives III. Synthesis of esters of dextran with n-substituted amino acids by the mixed anhydride method and study of the conditions for eliminating the protective groups. Chem Nat Compd 7, 679–684 (1971). https://doi.org/10.1007/BF00567916
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00567916