Synthesis of modified lysozyme inhibitors by the oxazoline method
The following glycosides of tri- and tetrasaccharides have been synthesized by the oxazoline method: GNAc-(1 → 6)-GNAc-(1 → 4)-GNAc-OC6H4NO2 and GNAc-(1 → 4)-GNAc-(1 → 6)-GNAc-(1 → 4)-GNAc-OC6H4NO2.
Information has been given on the inhibition by these compounds and other triosides of the lysis of the bacterial walls ofM. lysodeikticus by lysozyme.
It has been shown that a change in the positions of the glucosaminidic bonds between the monosaccharide units in the modified inhibitors does not deprive them of their affinity for the active center of lysozyme, but their inhibiting activity depends substantially on the sequence of position of the glucosaminidic bonds.
KeywordsGlycoside Lysozyme Nitromethane Sodium Methoxide DMFA
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- 1.E. A. Shashkova, I. V. Bikha, A. A. Vichutinskii, and A. Ya. Khorlin, Biokhimiya,35, 124 (1970).Google Scholar
- 4.T. S. Antonenko, S. É. Zurabyan, and A. Ya. Khorlin, Izv. Akad. Nauk SSSR, Ser. Khim.,1970, 2766.Google Scholar
- 6.L. M. Likhosherstov and L. É. Brossar, Khim. Prirodn. Soedin.,3, 7 (1967).Google Scholar
- 7.I. J. Goldstein, G. W. Hay, B. A. Lewis, and F. Smith, in: Methods of Carbohydrate Chemistry, Academic Press, Vol. 5 (1965), p. 361.Google Scholar
- 8.S. É. Zurabyan, T. P. Volosyuk, and A. Ya. Khorlin, Izv. Akad. Nauk SSSR, Ser. Khim.,1968, 1612.Google Scholar
- 9.A. Ya. Khorlin, M. L. Shul'man, S. É. Zurabyan, I. M. Privalova, and Yu. L. Kopaevich, Izv. Akad. Nauk SSSR, Ser. Khim.,1968, 2094.Google Scholar