Chemistry of Natural Compounds

, Volume 4, Issue 1, pp 1–5 | Cite as

Synthesis and biological activity of methyl derivatives of dl-19-nor-D-homotestosterone

  • K. K. Koshoev
  • I. G. Romanova
  • S. N. Ananchenko
  • I. V. Torgov
  • T. I. Barkova
  • I. B. Sorokina
Article

Summary

The synthesis of racemates of the 2α-methyl, 4-methyl, 17α-methyl, and 2α, 17α-dimethyl derivatives of 19-nor-D-homotestosterone has been described. Biological tests have shown that the introduction of a CH3 group into positions 2α and 17α totally suppresses both androgenic and anabolic activity. The introduction of a CH3 group into position 4 leads to a divergence of the anabolic and androgenic effects.

Keywords

Methyl Iodide Methyl Ether Sodium Hydride Androgenic Activity Raney Nickel 

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Copyright information

© The Faraday Press, Inc 1969

Authors and Affiliations

  • K. K. Koshoev
    • 1
  • I. G. Romanova
    • 1
  • S. N. Ananchenko
    • 1
  • I. V. Torgov
    • 1
  • T. I. Barkova
    • 1
  • I. B. Sorokina
    • 1
  1. 1.Institute of the Chemistry of Natural Compounds, AS USSRUSSR

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