Chemistry of Natural Compounds

, Volume 11, Issue 5, pp 666–669 | Cite as

Synthesis of Z-L-Phe-L-His-L-Leu, a substrate of carboxycathepsin

  • V. F. Pozdnev
  • S. I. Dolinskaya
  • N. N. Uvarova
  • E. S. Chaman


It has been shown that in the synthesis of the peptide Z-L-Phe-L-His-L-Leu by various methods, the best results are obtained by extending the peptide chain from the C-end by the method using activated N-hydroxysuccinimide esters.


Ethyl Acetate Methyl Ester DMFA Hydantoin Benzyloxy 


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Literature cited

  1. 1.
    Enzyme Nomenclature Recommendations (1972) of the Commission on Biochemical Nomenclature (1973).Google Scholar
  2. 2.
    Yu. E. Eliseeva, V. N. Orekhovich, L. N. Pavlikhina, and L. T. Alekseenko, Vopr. Med. Khim.,16, 646 (1970).PubMedGoogle Scholar
  3. 3.
    J. Piquilloud, A. Reinharz, and M. Roth, Biochem. Biophys. Acta,206, 136 (1970).PubMedGoogle Scholar
  4. 4.
    A. Ide, K. Shigezane, T. Mizoguchi, and S. Sorito, J. Pharm. Soc. Japan,90, 859 (1970).CrossRefGoogle Scholar
  5. 5.
    E. Shroeder and K. Lübke, The Peptides, Academic Press, New York (1965).Google Scholar
  6. 6.
    V. F. Pozdnev, Khim. Prirodn. Soedin., 384 (1971).Google Scholar
  7. 7.
    V. F. Pozdnev, Khim. Prirodn. Soedin., 764 (1974).Google Scholar
  8. 8.
    W. J. Bailey and H. J. Booth, J. Amer. Chem. Soc., Polym. Prepr.,13, 970 (1972).Google Scholar
  9. 9.
    E. Schnabel, H. Herzog, P. Hoffmann, E. Klauke, and I. Ugi, Ann. Chem.,716, 175 (1968).CrossRefGoogle Scholar
  10. 10.
    E. Schnabel, I. Stoltefuss, H. Offe, and E. Klauke, Ann. Chem.,743, 57 (1971).CrossRefGoogle Scholar
  11. 11.
    F. Schneider, Z. Physiol. Chem.,320, 829 (1960).CrossRefGoogle Scholar
  12. 12.
    E. Wunsch and A. Zwick, Chem. Ber.,97, 2497 (1964).CrossRefGoogle Scholar
  13. 13.
    R. W. Holley and E. Sondheimer, J. Amer. Chem. Soc.,76, 1326 (1964).CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • V. F. Pozdnev
  • S. I. Dolinskaya
  • N. N. Uvarova
  • E. S. Chaman

There are no affiliations available

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