Summary
1. The conformational states of glycine residues — R, B, L, P — in the low-energy forms of the tripeptides (I–III) are found with equal frequency.
2. The conformations of the main chain in sections of protein with glycine residues correspond to the preferred forms of the tripeptide fragments (I–III).
3. The close-, medium-, and long-range interactions in proteins do not contradict one another and exist at the favorable forms of the main chain.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature cited
M. Goodman, M. Langsam, and J. G. Rosen, Biopolymers,4, 305 (1966).
M. Goodman, A. S. Verdini, C. Toniolo, W. D. Phillips, and F. A. Bovey, Proc. Nat. Acad. Sci. U.S.,64, 444 (1969).
M. Goodman, F. Naider, and C. Toniolo, Biopolymers,10, 1719 (1971).
M. Goodman, F. Naider, and R. Rupp, Bioorg. Chem.,1, 310 (1971).
A. Yoron, E. Katchalski, A. Berger, G. D. Fasman, and H. A. Sober, Biopolymers,10, 1107 (1971).
S. Kawanishi and S. Sano, Biopolymers,12, 3166 (1973).
P. K. Ponnuswamy, P. K. Warme, and H. A. Scheraga, Proc. Nat. Acad. Sci., US,70, 830 (1973).
D. A. D. Parry and E. Suzuki, Biopolymers,7, 189 (1969).
G. M. Lipkind and E. M. Popov, Int. J. Pept. Prot. Res.,5, 371 (1973).
G. M. Lipkind, S. F. Arkhipova, and E. M. Popov, Molekul. Biol.,4, 331 (1970).
G. M. Lipkind, S. F. Arkhipova, and E. M. Popov, Molekul. Biol.,4, 509 (1970).
M. A. Kreissler, N. A. Ahmedov, G. M. Lipkind, S. F. Arkhipova, and E. M. Popov, J. Chim. Phys.,71, 913 (1974).
V. Z. Pletnev, É. P. Gromov, and E. M. Popov, Khim. Prirodn. Soedin., 618 (1975).
E. P. Gromov, V. Z. Pletnev, and E. M. Popov, Khim. Prirodn. Soedin., 626 (1975).
V. Z. Pletnev, F. A. Kadymova, and E. M. Popov, Molekul. Biol.,9, No. 2, 213 (1975).
I. A. Schellman, Compt. Rend. Trav. Lab. Carlsberg, Ser. Chim.,29, 223 (1955).
J. M. Klotz and J. S. Fransen, J. Amer. Chem. Soc.,84, 3461 (1962).
V. Z. Pletnev, E. P. Gromov, and E. M. Popov, Khim. Prirodn. Soedin., 224 (1973).
E. M. Popov, G. M. Lipkind, S. F. Arkhipova, and V. G. Dashevskii, Molekul Biol., 622 (1968).
G. M. Lipkind, S. F. Arkhipova, and E. M. Popov, Zh. Strukt. Khim.,11, 121 (1970).
R. A. Scott and H. A. Scheraga, J. Chem. Phys.,45, 2091 (1966).
F. A. Momany, R. F. McQuire, J. F. Yan, and H. A. Scheraga, J. Phys. Chem.,75, 2286 (1971).
E. M. Popov, V. G. Dashevskii, G. M. Lipkind, and S. F. Arkhipova, Molekul. Biol.,2, 612 (1968).
IUPAC-IUB Commission on Biochemical Nomenclature, Biochemistry,9, 3471 (1971).
H. C. Watson, Progr. Stereochem.,4, 229 (1969).
D. C. Phillips, Proc. Nat. Acad. Sci. U.S.,57, 484 (1967); G. N. Ramachandran and V. Sasisekharan, Advan. Protein Chem., 283 (1968).
J. J. Birktoft and D. M. Blow, J. Mol. Biol.,68, 187 (1972).
W. N. Lipscomb, G. M. Reeke, J. Jean, A. Hartsuck, F. A. Quiocho, and P. H. Bethpage, Phil. Trans. Roy. Soc.,B 257, 177 (1970).
R. E. Dickerson, T. Takano, D. Eisenberg, O. B. Kallai, L. Samson, A. Cooper, and T. Margoliash, J. Biol. Chem.,246, 1511 (1971); T. T. Wu and E. A. Kabat, J. Mol. Biol.,75, 13 (1973).
T. L. Blundell, J. F. Cutfield, E. J. Dodson, G. G. Dodson, D. C. Hodgkin, D. A. Mercola, and M. Vilayan, Nature (Lond),231, 506 (1971).
P. N. Lewis, F. A. Momany, and H. A. Scheraga, Biochim. Biophys. Acta,303, 211 (1973).
E. M. Popov and G. M. Lipkind, Molekul. Biol.,5, 624 (1971).
G. M. Lipkind and E. M. Popov, Molekul. Biol.,5, 667 (1971).
Additional information
M. M. Shemyakin Institute of Bioorganic Chemistry, Academy of Sciences of the USSR. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 631–637, September–October, 1975.
Rights and permissions
About this article
Cite this article
Pletnev, V.Z., Kadymova, F.A. & Popov, E.M. Theoretical conformational analysis of tripeptides with a glycine residue. Chem Nat Compd 11, 660–665 (1975). https://doi.org/10.1007/BF00567707
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF00567707