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A study of enzyme-substrate compounds

II. Preparation of acyl-L-valyl, D-valyl, and D-phenylalanyl derivatives of chymotrypsin

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Chemistry of Natural Compounds Aims and scope

Summary

1. From the reaction of chymotrypsin with the NPE of CBZ-L- and CBZ-D-valine the enzyme-substrate compounds CBZ-L-valylchymotrypsin and CBZ-D-valylchymotrypsin have been isolated. The methyl esters of benzoyl-D-phenylalanine and of benzoyl-L-valine also form enzyme-substrate compounds with chymotrypsin, although to a smaller extent. The methyl ester of benzoyl-D-valine does not react with chymotrypsin.

2. Conditions for the isolation of a water-soluble enzyme-substrate compound have been found.

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Authors and Affiliations

  1. Lomonosov Moscow State University, USSR

    M. M. Botvinik, I. P. Kuranova & L. L. Ivanov

Authors
  1. M. M. Botvinik
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  2. I. P. Kuranova
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  3. L. L. Ivanov
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Additional information

Khimiya Prirodnykh Soedinenii, Vol. 2, No. 2, pp. 134–138, 1966

Given at the First All-Union Biochemical Congress, 25 January 1964 (Leningrad).

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Botvinik, M.M., Kuranova, I.P. & Ivanov, L.L. A study of enzyme-substrate compounds. Chem Nat Compd 2, 105–108 (1966). https://doi.org/10.1007/BF00567546

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  • DOI: https://doi.org/10.1007/BF00567546

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