Chemistry of Natural Compounds

, Volume 2, Issue 2, pp 83–88 | Cite as

The structure of thalmine

  • M. V. Telezhenetskaya
  • Z. F. Ismailov
  • S. Yu. Yunusov


1. On the basis of the isolation of 2-methoxy-1-1′-diphenyloxide-4′,5-dicarboxylic acid (I) it has been established that thalmidine and thalmine are bis-benzylisoquinoline bases.

2. By the preparation of (+)-N-methylisococlaurine and (+)-O-methylarmepavine it has been shown that thalmidine is identical with O-methylthalicberine.

3. The nature of the degradation products isolated shows that thalmine has the LL configuration.

4. Since the diaminodialdehydes obtained by the ozonolysis of the des-bases of O-methylthalmine, O-methyloxyacanthine, and hernandezine are not identical, structure (VII) (taking the degradation products into account) is proposed for thalmine.


Methyl Iodide Methoxyl Group Potassium Permanganate Liquid Ammonia Monoethanolamine 


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Copyright information

© The Faraday Press, Inc 1967

Authors and Affiliations

  • M. V. Telezhenetskaya
    • 1
  • Z. F. Ismailov
    • 1
  • S. Yu. Yunusov
    • 1
  1. 1.Institute of the Chemistry of Plant Substances, AS UzSSRUSSR

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