Conclusions
The synthesis of the heptapeptideN ɛ-BOC-N α-pelargonyl-L-lysyl-N ɛ-Z-L-lysyl-D-phenylalanyl-L-leucyl-N ɛ-Z-L-lysyl-N ɛ-Z-L-lysyl-L-threonine, a linear analog of the cyclopeptide part of the antibiotic polymixin B, has been effected (yield 63%). The possibility of using this method for the synthesis of peptides on a polymer support without protecting the hydroxyl group of threonine has been shown.
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Khimiya Prirodnykh Soedinenii, Vol. 6, No. 3, pp. 359–361, 1970
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Morozova, E.A., Zevail', M.A. Synthesis of the heptapeptide of the cyclopeptide moiety of polymixin B. Chem Nat Compd 6, 358–359 (1970). https://doi.org/10.1007/BF00567320
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DOI: https://doi.org/10.1007/BF00567320