Chemistry of Natural Compounds

, Volume 6, Issue 3, pp 358–359 | Cite as

Synthesis of the heptapeptide of the cyclopeptide moiety of polymixin B

  • E. A. Morozova
  • M. A. Zevail'


The synthesis of the heptapeptideNɛ-BOC-Nα-pelargonyl-L-lysyl-Nɛ-Z-L-lysyl-D-phenylalanyl-L-leucyl-Nɛ-Z-L-lysyl-Nɛ-Z-L-lysyl-L-threonine, a linear analog of the cyclopeptide part of the antibiotic polymixin B, has been effected (yield 63%). The possibility of using this method for the synthesis of peptides on a polymer support without protecting the hydroxyl group of threonine has been shown.


Pelargonic Acid Triethylamine Hydrochloride Diaminobutyric Acid Weakly Acid Reaction Attached Amino Acid 


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Copyright information

© Consultants Bureau 1973

Authors and Affiliations

  • E. A. Morozova
    • 1
  • M. A. Zevail'
    • 1
  1. 1.Moscow State UniversityUSSR

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