Summary
By the reaction of α-hydroxymethylene- and α-dimethylaminomethylene-2,3-polymethylene-3,4-dihydroquinazolin-4-ones with acid anhydrides and primary and secondary amines, the corresponding α-acyloxymethylene- and α-mono(di)-substituted aminomethylene-2,3-polymethylene-3,4-dihydroquinazolin-4-ones have been synthesized. The addition of hydrocyanic acid (from acetone cyanohydrin) to the double bond of the methylene group of the α-hydroxymethylene- and α-dimethylaminomethylene-2,3-trimethylene-3,4-dihydroquinazolin-4-ones has led to α-[cyano-(hydroxy)methyl1]- and α-[cyano(dimethylamino)methyl]-2,3-trimethylene-3,4-dihydroquinazolin-4-ones.
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Literature cited
French Patent No. 2,098,361 (1962); Izobret. za Rubezhom, Issue 1, No. 6, 61 (1972).
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Additional information
Institute of the Chemistry of Plant Substances, Academy of Sciences of the Uzbek SSR, Tashkent. Translated from Khimiya Prirodnykh Soedinenii, No. 5, pp. 603–609, September–October, 1978.
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Oripov, É., Yun, L.M., Shakhidoyatov, K.M. et al. Some reactions of α-hydroxymethylene- and α-dimethylaminomethylene-2,3-polymethylene-3,4-dihydroquinazolin-4-ones. Chem Nat Compd 14, 518–523 (1978). https://doi.org/10.1007/BF00567147
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DOI: https://doi.org/10.1007/BF00567147