Chemistry of Natural Compounds

, Volume 11, Issue 1, pp 67–70 | Cite as

Synthesis of methyl esters of Nα-arylsulfonyl derivatives ofl-arginine — Substrates of trypsin and thrombin

  • S. B. Serebryanyi
  • D. M. Fedoryak
  • V. K. Kibirev
Article
  • 21 Downloads

Summary

1. For a comparative study of the esterase activities of trypsin and thrombin on synthetic substrates we have obtained a number of Nα-arylsulfonyl derivatives ofl-arginine and their methyl esters containing substituents with different electronic natures and volumes in the benzene ring.

2. The UV spectra and the ORD spectra of the compounds obtained have been studied.

Keywords

Methyl Ester Thrombin Methyl Ethyl Thionyl Chloride Vacuum Desiccator 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    R. H. Andreatta, R. K. H. Liem, and H. A. Scheraga, Proc. Nat. Acad. Sci.,68, 253 (1971).CrossRefGoogle Scholar
  2. 2.
    R. K. H. Liem, R. H. Andreatta, and H. A. Scheraga, Arch. Biochem. Biophys.,147, 201 (1971).CrossRefGoogle Scholar
  3. 3.
    S. B. Serebryanyi, L. G. Yurganova, and V. M. Neplyuev, Ukr. Khim. Zh.,27, 365 (1961).Google Scholar
  4. 4.
    S. B. Serebryanyi, L. G. Yurganova, and N. E. Fedorova, Biokhimiya,33, 3 (1968).Google Scholar
  5. 5.
    L. G. Yurganova and N. E. Fedorova, Biokhimiya,35, 493 (1970).Google Scholar
  6. 6.
    M. Brenner and W. Huber, Helv. Chim. Acta,36, 1109 (1953).CrossRefGoogle Scholar
  7. 7.
    E. H. Huntress and J. S. Autenrieth, J. Amer. Chem. Soc.,63, 3446 (1941).CrossRefGoogle Scholar
  8. 8.
    E. Lunt, J. Appl. Chem.,7, 446 (1957).CrossRefGoogle Scholar
  9. 9.
    S. Smiles and J. Stewart, J. Chem. Soc., 1792 (1921).Google Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • S. B. Serebryanyi
  • D. M. Fedoryak
  • V. K. Kibirev

There are no affiliations available

Personalised recommendations