Chemistry of Natural Compounds

, Volume 11, Issue 4, pp 513–516 | Cite as

Synthesis of [4-histidine]oxytocin

  • M. A. Samartsev
  • T. K. Lozhkina
  • V. F. Martynov


A new synthetic analog of oxytocin — [4-histidine] oxytocin — has been obtained and its uterotonic activity has been determined.


Oxytocin Hydrazide Hydrobromide DMFA Peptide Peak 


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Literature cited

  1. 1.
    J. Rudinger, O. V. Kesarev, K. Poduska, B. Pickering, R. Dyball, D. Ferguson, and W. Ward, Experientia,25, 680 (1969).CrossRefGoogle Scholar
  2. 2.
    M. Manning, E. Coy, and W. Sawyer, Biochemistry,9, 3925 (1970).CrossRefGoogle Scholar
  3. 3.
    W. Sawyer, M. Manning, E. Heinicke, and A. Perks, Gen. Comp. Endocrinology,12, 387 (1969).CrossRefGoogle Scholar
  4. 4.
    V. Hruby, G. Flouret, and V. du Vigneaud, J. Amer. Chem. Soc.,244, 3890 (1969).Google Scholar
  5. 5.
    O. A. Kaurov, V. F. Martynov, and Yu. D. Mikhailov, Zh. Obshch. Khim.,41, 1413 (1971).Google Scholar
  6. 6.
    I. Photaki and V. du Vigneaud, J. Amer. Chem. Soc.,87, 908 (1965).CrossRefGoogle Scholar
  7. 7.
    W. Sawyer, T. Wuu, J. Baxter, and M. Manning, Endocrinolgy,85, 385 (1969).CrossRefGoogle Scholar
  8. 8.
    M. Bodanszky and V. du Vigneaud, J. Amer. Chem. Soc.,81, 5688 (1959).CrossRefGoogle Scholar
  9. 9.
    Zh. D. Bespalova, T. K. Lozhkina, M. A. Samartsev, and I. M. Shchenkova, Khim. Prirodn. Soedin., 808 (1973).Google Scholar
  10. 10.
    L. Moroder, G. Borin, F. Marchiori, and E. Scoffone, Biopolymers,12, 521, 701 (1973).CrossRefGoogle Scholar
  11. 11.
    D. Yamashiro, D. Hope, and V. du Vigneaud, J. Amer. Chem. Soc.,90, 3857 (1958); M. Manning, T. Wuu, and J. Baxter, J. Chromatogr.,38, 396 (1968).CrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1976

Authors and Affiliations

  • M. A. Samartsev
  • T. K. Lozhkina
  • V. F. Martynov

There are no affiliations available

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