Chemistry of Natural Compounds

, Volume 15, Issue 5, pp 601–603 | Cite as

Preparation of hydrazides of amino acids and peptides

  • E. P. Krysin
  • V. N. Karel'skii
  • A. A. Antonov
  • G. E. Rostovskaya


A new method of synthesizing hydrazides of amino acids and peptides is considered which involves the hydrazinolysis of the silyl esters of the corresponding compounds. A number of hydrazides of derivatives of amino acids and peptides has been obtained in high purity with yields close to quantitative. The physicochemical characteristics of the compounds synthesized are given.


Hydrazine Ethyl Ester Hydrazide Hydrazine Hydrate Silyl 


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Literature cited

  1. 1.
    E. Schroeder and K. Lübke, The Peptides, Academic Press, New York (1965); J. Greenstein and M. Winitz, Chemistry of the Amino Acids, Wiley, New York (1961).Google Scholar
  2. 2.
    R. Schwyzer and W. Rittel, Helv. Chim. Acta,44, No. 1, 159 (1961).CrossRefGoogle Scholar
  3. 3.
    E. P. Krysin, V. N. Karel'skii, A. A. Antonov, and G. E. Rostovskaya, Method of Obtaining Hydrazides of N-substituted Amino Acids or Peptides. Supplementary Decision of December 20, 1978, on Application No. 093520.Google Scholar
  4. 4.
    J. F. Klebe, H. Finkbeiner, and D. M. White, J. Am. Chem. Soc.,88, 3390 (1966).CrossRefGoogle Scholar
  5. 5.
    L. Sommer, Stereochemistry, Mechanism and Silicon: an Introduction to the Thermodynamic Stereochemistry and Reaction Mechanism of Silicon Centers, McGraw-Hill, New York (1905).Google Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • E. P. Krysin
  • V. N. Karel'skii
  • A. A. Antonov
  • G. E. Rostovskaya

There are no affiliations available

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