Chemistry of Natural Compounds

, Volume 15, Issue 4, pp 466–468 | Cite as

Cardenolide and bufadienolide derivatives of ajmaline

  • I. F. Makarevich
  • Ya. I. Khadzhai
  • A. V. Nikolaeva
  • V. V. Pavlova


A description is given of the synthesis of new compounds — 3-O-(ajmalin-N(b)-ioacetyl)strophanthidin and 3-O-(ajmalin-N(b)-ioacetyl)hellebrigenin bromides — possessing antiarrhythmic and cardiotonic activity. The synthesis was performed in two stages: 1) a preparation of halogen derivatives of the cardiac aglycones by acylating them with bromoacetyl bromide; and 2) the reaction of the alkaloid ajmaline with the halogen derivatives of the cardiac aglycones to quaternary salts.


Cardiac Contraction Cardenolides Antiarrhythmic Activity Quaternary Salt Ajmaline 


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Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • I. F. Makarevich
  • Ya. I. Khadzhai
  • A. V. Nikolaeva
  • V. V. Pavlova

There are no affiliations available

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