Oxidation of ergosterol acetate with chromic anhydride
The conditions for the oxidation of ergosterol acetate with chromic anhydride have been studied, and it has been shown that the yield of the 3β-acetoxy-5α-hydroxyergosta-7,22-dien-6-one (Burawoy's ketone) so obtained is a maximum when oxidation is performed in ether.
On the basis of the results obtained, a multistage mechanism for the oxidation of ergosterol acetate is suggested.
KeywordsKetone Triol Ecdysterones Chromium Trioxide Hydroxy Ketone
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