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Chemistry of Natural Compounds

, Volume 8, Issue 1, pp 89–92 | Cite as

Synthesis of [1-asparagine, 3-glycine, 5-valine]angiotensin II

  • R. É. Vegner
  • G. I. Chipens
Article

Summary

1. [1-Asparagine, 3-glycine, 5-valine]angiotensin II has been synthesized by the classical methods of peptide chemistry and its pressor activity has been determined.

The main function of the amino acid in position 3 of the angiotensin molecule is to ensure the spatial direction of the arrangement of the NH2-terminal dipeptide by steric (intramolecular) and hydrophobic (in-termolecular) interactions.

Keywords

Dipeptide Hydrogen Chloride Sodium Hydrogen Carbonate Palladium Black Nitroarginine 

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Copyright information

© Consultants Bureau, a division of Plenum Publishing Corporation 1974

Authors and Affiliations

  • R. É. Vegner
    • 1
  • G. I. Chipens
    • 1
  1. 1.Academy of Sciences of the Latvian SSRInstitute of Organic SynthesisRussia

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