Chemistry of Natural Compounds

, Volume 9, Issue 5, pp 621–624 | Cite as

Experimental results relating to the metabolism of the cardiac glycosides

  • M. A. Angarskaya
  • L. Ya. Topchii
Article
  • 29 Downloads

Summary

1. The metabolism of nine cardenolides — convallatoxin, convallatoxol, erychroside, erychrosol, securiside, securisidol, gofruside, frugoside, and erysimin — has been studied at the stage of passage through the liver and in the pathways of excretion by the kidneys.

2. It has been found that the aldehyde at the C19 group of the cardiac glycosides studied is reduced to an alcohol group.

3. Erysimin differs in its metabolism from the other glycosides studied by the fact that in addition to the production of a form reduced at C19 it undergoes hydrolytic cleavage with the production of the genin. A third metabolite has not been identified and has provisionally been called metabolite M.

Keywords

Glycoside Zinc Acetate Methyl Ethyl Cardiac Glycoside Cardenolides 

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Literature cited

  1. 1.
    W. Neumann, Arch. Exptl. Pathol. Pharmakol.,208, 46 (1949).Google Scholar
  2. 2.
    A. Stoll and J. Renz, Helv. Chim. Acta,34, 782 (1951).CrossRefGoogle Scholar
  3. 3.
    F. Lauterbach and K. Repke, Arch. Exptl. Pathol. Pharmakol.,239, 196 (1960).CrossRefGoogle Scholar
  4. 4.
    P. I. Gvozdyak and D. G. Kolesnikov, Med. Prom. SSSR,7, 14 (1961).Google Scholar
  5. 5.
    A. Gubler and Ch. Tamm, Helv. Chim. Acta,41, 297 (1958).CrossRefGoogle Scholar
  6. 6.
    H. Nama, M. Uchibayaschi, and T. Kamiya, Nature,184, 469 (1959).CrossRefGoogle Scholar
  7. 7.
    K. Repke, Arch. Exptl. Pathol. Pharmakol.,237, 34 (1956).Google Scholar
  8. 8.
    I. Herrmann and K. Repke, Arch. Exptl. Pathol. Pharmakol.,248, 351 (1964).Google Scholar
  9. 9.
    F. Lauterbach, D. Nitz, and K. Prescher, Arch. Exptl. Pathol. Pharmakol.,247, 71 (1964).CrossRefGoogle Scholar
  10. 10.
    R. Megges and K. Repke, Arch. Exptl. Pathol. Pharmakol.,241, 534 (1961).CrossRefGoogle Scholar
  11. 11.
    W. A. Jacobs, J. Biol. Chem.,57, 553 (1923).Google Scholar

Copyright information

© Plenum Publishing Corporation 1975

Authors and Affiliations

  • M. A. Angarskaya
  • L. Ya. Topchii

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