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Mechanism of the inactivation of the antibiotic polymyxin M

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Chemistry of Natural Compounds Aims and scope

Summary

1. A method for the separation and quantitative determination of α- and ω-DNP derivatives of α, γ-DABA, ornithine, and lysine has been proposed.

2. A quantitative evaluation of the Nα ⇄ Nγ migration in four peptides of α, γ-DABA has been carried out.

3. The degree of migration in inactive polymyxin M and the DNP-peptides from a partial hydrolyzate of the inactivated antibiotic has been determined.

4. The amino acid composition of the DNP peptide B1 from a partial hydrolyzate of active DNP-polymyxin M has been established.

5. The quantitative aspect of the conversion of\({\text{D}}{\text{A}}\) and\({\text{g}}{\text{A}}\) diketopiperazines has been studied.

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Khimiya Prirodnykh Soedinenii, Vol. 2, No. 4, pp. 277–284, 1966

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Baratova, L.A., Katrukha, G.S. & Silaev, A.B. Mechanism of the inactivation of the antibiotic polymyxin M. Chem Nat Compd 2, 224–229 (1966). https://doi.org/10.1007/BF00564095

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