Chemistry of Natural Compounds

, Volume 2, Issue 4, pp 219–223 | Cite as

Cleavage of the peptide chain of blood-group substances at the hydroxyamino acid links

  • V. A. Derevitskaya
  • S. G. Kara-Murza
  • N. K. Kochetkov


1. A method for the cleavage of the peptide chain of glycoproteins containing O-glycosidic bonds of hydroxyamino acids based on the introduction into the peptide chain of reactive enamine groupings through the β-elimination of the carbohydrate moieties has been proposed for the first time.

2. The degradation based on this principle of the peptide chain of blood group substances A + H has been effected. Various conditions for this degradation and also the dependence of the degree of degradation on the conditions of β-elimination have been studied.

3. The basic structural nature of the molecule of blood group substance A + H has been deduced. The skeleton of the molecule is a long polypeptide chain.


Bromine Peptide Chain Caustic Soda Peptide Fraction Mild Acid Hydrolysis 


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Copyright information

© The Faraday Press, Inc 1967

Authors and Affiliations

  • V. A. Derevitskaya
    • 1
  • S. G. Kara-Murza
    • 1
  • N. K. Kochetkov
    • 1
  1. 1.Institute of the Chemistry of Natural Compounds, AS USSRUSSR

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