Chemistry of Natural Compounds

, Volume 2, Issue 4, pp 214–218 | Cite as

Synthesis of depsipeptide analogs of bradykinin

  • L. A. Shchukina
  • G. A. Ravdel
  • M. P. Filatova


The syntheses of three depsipeptide analogs of bradykinin have been effected. The replacement of one or even two peptide linkages in the molecule of bradykinin by ester linkages does not affect the nature of its biological activity but only reduces it. These results show that a continuous peptide chain is not unconditionally necessary for the appear -ance of the specific biological activity of bradykinin.


Glacial Acetic Acid Bradykinin Hydrobromide Depsipeptide Palladium Black 


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Copyright information

© The Faraday Press, Inc 1967

Authors and Affiliations

  • L. A. Shchukina
    • 1
  • G. A. Ravdel
    • 1
  • M. P. Filatova
    • 1
  1. 1.Institute of the Chemistry of Natural Compounds, AS USSRUSSR

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